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- Table of Contents
Anoctamin-1 Antibodies
AND ANO1 ELISA kits, Anoctamin-1 Proteins
Many biological assays use antibodies to detect Anoctamin-1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Anoctamin-1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Anoctamin-1 antibodies...
Designing a Western blot for Anoctamin-1? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the ANO1 Western Blot GuideANO1 Infographic by Boster Bio
All ANO1 Products
Product
Figures
Specificity
Applications
Price
Anti-TMEM16A/ANO1 Antibody Picoband®
1 Citations
Human
Flow Cytometry, IHC, WB
$370
Cat # A00713
100 μg/vial
Cat # A00713
100 μg/vial
Human
ELISA, Flow Cytometry, Functional Assay, Kinetics
$486
Cat # M00713-2
100 μg
Cat # M00713-2
100 μg
Human, Mouse, Rat
IHC, WB
$523
Cat # M00713
100 µl
Cat # M00713
100 µl
ANO1 Overview
Facts about Anoctamin-1.
Anoctamin-1 (ANO1)
Calcium-activated chloride channel (CaCC) which plays a role in transepithelial anion transport and smooth muscle contraction. Required for the normal functioning of the interstitial cells of Cajal (ICCs) which generate electrical pacemaker activity in gastrointestinal smooth muscles.
Acts as a major contributor to both basal and stimulated chloride conductance in airway epithelial cells and plays an important role in tracheal cartilage development. .
Gene Information
| Human | |
|---|---|
| Gene Name: | ANO1 |
| Uniprot: | Q5XXA6 |
| Entrez: | 55107 |
Family
| Belongs to: |
|---|
| anoctamin family |
Alternative Names
ANO1; anoctamin 1; DOG1; ORAOV2; TAOS2; TMEM16A
Molecular Weight
Mass (kDA):
114.078 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 11q13.3 |
| Sequence: | 11; NC_000011.10 (69985907..70189530) |
Tissue Specificity
Broadly expressed with higher levels in liver, skeletal muscle and gastrointestinal muscles.
Subcellular Localizations
Cell membrane; Multi-pass membrane protein. Cytoplasm. Cytoplasmic localization seen in neoplastic cells of head and neck squamous cell carcinoma (HNSCC) tumors.
Diseases
- Neoplasms
- Gastrointestinal Stromal Tumors
- Cystic Fibrosis
- Fibrosis
- Stromal Neoplasm
- Intrahepatic Cholangiocarcinoma
- Malignant Neoplasms
- Carcinoma
- Sarcoma
- Synovial Sarcoma
- Hypertensive Disease
- Neoplasm Metastasis
- Gastrointestinal Neoplasms
Pathways
- Secretion
- Transport
- Muscle Contraction
- Smooth Muscle Contraction
- Localization
- Cell Proliferation
- Ion Transport
- Membrane Depolarization
- Vasoconstriction
- Fluid Transport
- Chloride Transport
- Peristalsis
- Pathogenesis
PTMs
- Phosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ANO1
bosterbio.com/bosterbio-gene-info-cards/ANO1
References
PMID: 16906560 by Huang X., et al. Comprehensive genome and transcriptome analysis of the 11q13 amplicon in human oral cancer and synteny to the 7F5 amplicon in murine oral carcinoma.
PMID: 12739008 by Katoh M., et al. FLJ10261 gene, located within the CCND1-EMS1 locus on human chromosome 11q13, encodes the eight-transmembrane protein homologous to C12orf3, C11orf25 and FLJ34272 gene products.
1 Publications of Boster Anoctamin-1 Antibodies & ELISA Kits
- PubMed ID: 10.1096/fasebj.2020.34.s1.06115, Intestinal TMEM16A function as a luminal chloride channel
*More publications can be found for each product on its corresponding product page