Annexin A5 Antibodies

Annexin A5 (ANXA5)

This protein is an anticoagulant protein that serves as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade. .

Gene Information

Human
Gene Name:	ANXA5
Uniprot:	P08758
Entrez:	308

Family

Belongs to:
annexin family

Alternative Names

Anchorin CII; annexin A5; Annexin V; annexin-5; ANX5; ANXA5; ANXV; Calphobindin I; Endonexin II; ENX2CBP-I; Lipocortin V; PAP-I; Placental anticoagulant protein 4; Placental anticoagulant protein I; PP4; Thromboplastin inhibitor; VAC-alpha; Vascular anticoagulant-alpha

Molecular Weight

Mass (kDA):
35.937 kDA

Genomic Context

Human
Location:	4q27
Sequence:	4; NC_000004.12 (121667946..121696994, complement)

Diseases

• Inflammation
• Thrombosis
• Malignant Neoplasms
• Neoplasms
• Atherosclerosis
• Antiphospholipid Syndrome
• Carcinoma
• Acute Promyelocytic Leukemia
• Lupus Erythematosus, Systemic
• Pregnancy Complications

• Thrombophilia
• Cardiovascular Diseases
• Neoplasm Metastasis
• Polyendocrinopathies, Autoimmune
• Autoimmune Reaction

Interacting Proteins

• TINF2

Pathways

• Coagulation
• Cell Death
• Pathogenesis
• Localization
• Immune Response
• Phagocytosis
• Cell Differentiation
• Conjugation
• Exocytosis
• Hemostasis
• Blood Coagulation
• Cell Proliferation
• Endocytosis

• Methylation
• Regeneration
• Secretion
• Cell Adhesion
• Transport
• Transposition
• Programmed Cell Death

PTMs

• Phosphorylation
• Methylation

• Carboxylation
• Reduction

• Dephosphorylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ANXA5

Boster Bio - Best Uses Of The ANXA5 Marker

It is essential to optimize your research when using the Boster Bio. The optimization tips and guides that come with this reagent can help you optimize your experiment and improving results. Even with the best control methods, experiments are likely to have issues. Troubleshooting guides will help you isolate potential sources of error and provide solutions. You'll be able obtain better results than you'd imagined.

ANXA5

The ANXA5 gene is many potential uses in research. It is an important marker for studying gene expression in the heart, brain, and intestine. Boster Bio offers high affinity primary antibodies for this gene. They are validated on immunohistochemistry, Western blotting, and ELISA. These antibodies have been extensively used in research for a long time and are frequently referenced in scientific publications.

ANXA5 plays a significant role in the development of ectopic epimetriosis. It is associated with a high E2 concentration and is a marker of tumor metastasis. However, the molecular factors that play a role in the pathogenesis of adenomyosis remain elusive. However the ANXA5 gene has been proven to play an important part in regulating the epithelial to mesenchymal transition.

E2-induced up-regulation of ANXA2 is also linked to reduced expression of E-cadherin as well as the increase in vimentin and slug. This gene can be used in research to understand EMT and its potential therapeutic benefits. This marker is able to be used to detect Adenomyosis, an important step in the treatment of cancer. Because it blocks EMT and thereby reducing the risk of cancer, it is a promising tool for treating cancer.

Although this gene has numerous applications, the most significant one is that it lets doctors determine whether or not an individual suffers from endometriosis. The high levels of this gene is associated with the risk of recurrent endomyosis. The ectopic part of the endometrium also contains the protein. The ectopic uterus has an increased level of ANXA2 expression than eutopic endometrium.

AnxA2 plays an important role in adenomyosis pathogenesis. Aiming at patients suffering from this gene could be a promising treatment strategy. It is important that we understand the role of the ANXA2 gene in the development of adenomyosis. This gene will continue to be a valuable tool in the treatment of this disease.

One study showed that ANXA2-expressing cell lines showed higher the chemotactic activity as well as morphological differentiation in the adenomyosis. The development of blood vessels in newborns was also affected by the ANXA2 gene. In an alginate-encapsulated cell assay, ANXA2 shRNA inhibited the HIF-1a pathway and activated the VEGF-A pathway.

ANXA4

Boster Bio's Anti Annexin V/ANXA5 antibody reacts with Human, Mouse and Rat Annexin V. By using this antibody, researchers can determine the presence of ANXA5 and other genes present in their samples. These anti-annexin V antibodies can be used in various applications for tissue culture, cell culture , and other biomedical research.