Amyloid-like protein 2 Antibodies

Amyloid-like protein 2 (APLP2)

May play a role in the regulation of hemostasis. The soluble form could have inhibitory properties towards coagulation factors.

May interact with cellular G-protein signaling pathways. May bind to the DNA 5'-GTCACATG-3'(CDEI box).

Gene Information

Human
Gene Name:	APLP2
Uniprot:	Q06481
Entrez:	334

Family

Belongs to:
APP family

Alternative Names

amyloid beta (A4) precursor-like protein 2; amyloid precursor protein homolog HSD-2; Amyloid protein homolog; amyloid-like protein 2; APLP2; APLP-2; APPH; APPHCDEI box-binding protein; APPL2; CDEBP; WALPLP2; YWK-II

Molecular Weight

Mass (kDA):
86.956 kDA

Genomic Context

Human
Location:	11q24.3
Sequence:	11; NC_000011.10 (130069894..130144811)

Tissue Specificity

Expressed in placenta, brain, heart, lung, liver, kidney and endothelial tissues.

Subcellular Localizations

Cell membrane; Single-pass type I membrane protein. Nucleus.

Diseases

• Alzheimer's Disease
• Neuroblastoma
• Senile Plaques
• Tissue Adhesions
• Nervousness
• Plaque, Amyloid
• Neoplasms
• Alzheimer Disease, Familial
• Neurotoxicity Syndromes
• Malignant Neoplasms
• Infertility
• Nerve Degeneration
• Malnutrition

• Neurodegenerative Disorders
• Dementia
• Lissencephaly
• Neoplasm Metastasis
• Inflammation
• Pancreatic Neoplasm
• Cobblestone Lissencephaly

Interacting Proteins

• APLP1
• DEDD
• ETS1
• JUN
• MED12

Pathways

• Pathogenesis
• Secretion
• Cell Death
• Proteolysis
• Cell Adhesion
• Cell Migration
• Transport
• Endocytosis
• Localization
• Synaptic Transmission
• Rna Interference
• Brain Development
• Aging

• Wound Healing
• Regeneration
• Fertilization
• Cell Growth
• Cell Differentiation
• Cell Proliferation
• Glycosylation

PTMs

• Cleavage
• Phosphorylation
• Glycosylation
• Gamma-cleavage

• Acetylation
• Methylation
• Oxidation
• Myristoylation

Research Areas

• Signal Transduction

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/APLP2

Boster Bio Anti-Amyloid-Like Protein 2 APLP2 Marker

Are you wondering what the best uses for Boster Bio's Anti-Amyloid-like protein 2 marker are? You've reached the right place. Continue reading to find out more about Boster’s antimyloid-like-protein marker. This marker is widely used by researchers around the globe. This marker is extremely sensitive and can detect proteins in special specimens. Before you acquire the test, there are a few things that you need to know.

Boster Bio Anti-Amyloid-like protein 2 APLP2 Marker

Boster Bio Anti-Amyloid-Like Protein2 (APLP2) Marker uses a phosphorimaging technology. This technique detects a certain protein, APLP2. This study examined a group of patients for APLP2 protein expression. Tumors were graded according to the World Health Organization 1973 guidelines and Fuhrman et al. APLP2 expression was associated for survival in the population. There was no association between APLP2 gene expression and age.

The anti Amyloid-like protein-2 (APLP2) Marker is a polyclonal rabbit antibody. This antibody has been demonstrated to react with Human and Mouse cells as well as Rat cells. Boster Bio Anti-Amyloid-like proteins 2 APLP2 markers uses Human APLP2 as an antigen. They are suitable for Western Blot.

Clinical trials have demonstrated the use of APLP2 in the diagnosis of renal cell carcinoma. In patients with renal cancer, APLP2 expression was an independent predictor of survival. APLP2 expression was also associated to a lower overall survival among patients with CCRCC and distant metastasis.

81% of the human APLP2 genes are identical to those in mice and rats. However, expression and function are different in different tissues. Boster Bio Anti-Amyloid -Like Protein2 APLP2 Marker is thus appropriate. The Genome Browser of UCSC contains the human APLP2 genomic information.

Amyloid beta precursor protein-like proteins belong to the APP gene. APP undergoes proteolytic transformation to form Ab peptide. It is deposited inside the extracellular plaques for patients with Alzheimer's. Amyloid precursor proteins are structurally identical to APP and share many conserved domains.

APLP2 expression not only serves as a diagnostic biomarker of CCRCC but also associates with certain pathological features associated with RCC. Doctors can assess the effectiveness of treatment and diagnose RCC patients by evaluating APLP2 levels. These results are promising, but further study is needed to fully understand the molecular mechanisms of this protein in RCC.