ARHGEF1 Antibodies

AND ARHGEF1 ELISA kits, ARHGEF1 Proteins

Many biological assays use antibodies to detect ARHGEF1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ARHGEF1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ARHGEF1 antibodies...

We validate the specificity of these antibodies to ARHGEF1 by testing them on tissues known to express ARHGEF1 positively and negatively. Browse below to find the ARHGEF1 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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ARHGEF1 Infographic by Boster Bio

All ARHGEF1 Products

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Anti-ARHGEF1 Antibody Picoband®

3 Q&As

Western blot analysis of ARHGEF1 using anti-ARHGEF1 antibody (PB10045)

IHC analysis of ARHGEF1 using anti-ARHGEF1 antibody (PB10045)

Human, Mouse, Rat

Flow Cytometry, IF, IHC, ICC, WB

$370
Cat # PB10045
100 μg/vial

ARHGEF1 (NM_199002) Human Over-expression Lysate

ARHGEF1 Human Over-expression Lysates NM_198977

Human

$960
Cat # LS009138
20 µg, 100 µg

ARHGEF1 Overview

Facts about Rho guanine nucleotide exchange factor 1.

ARHGEF1 3D structure. Source: alphafold

Rho guanine nucleotide exchange factor 1 (ARHGEF1)

Appears to play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13) subunits. Acts as GTPase-activating protein (GAP) for GNA12 and GNA13, and as guanine nucleotide exchange factor (GEF) for RhoA GTPase.

Activated G alpha 13/GNA13 stimulates the RhoGEF activity through interaction with the RGS-like domain. This GEF activity is inhibited by binding to activated GNA12.

Gene Information

Human
Gene Name:	ARHGEF1
Uniprot:	Q92888
Entrez:	9138

Family

Belongs to:

No superfamily

Alternative Names

115 kDa guanine nucleotide exchange factor; 115-kD protein; GEF1; LBCL2LSC; Lsc homolog; p115RhoGEF; P115-RHOGEF; Rho guanine nucleotide exchange factor (GEF) 1; rho guanine nucleotide exchange factor 1; SUB1.5

Molecular Weight

Mass (kDA):
102.435 kDA

Genomic Context


Human

Location:	19q13.2
Sequence:	19; NC_000019.10 (41883184..41907452)

Tissue Specificity

Ubiquitously expressed.

Subcellular Localizations

Cytoplasm. Membrane. Translocated to the membrane by activated GNA13 or LPA stimulation.

Diseases

Tissue Adhesions
Hypertensive Disease
Inflammation
Inflammatory Response
Esophageal Achalasia
Pneumonia
Neoplasm Metastasis
Bacterial Peritonitis
Urinary Bladder Diseases
Metastatic Malignant Neoplasm To The Liver
Von Hippel-lindau Syndrome

Thymus Hyperplasia
Lung Diseases
Cardiovascular Diseases
Malignant Neoplasms
Neoplasms

Interacting Proteins

GNA13
TCF4

Pathways

Cell Migration
Immune Response
Leukocyte Migration
Inflammatory Response
Transport
Muscle Cell Differentiation
Ion Transport
Peristalsis
Adaptive Immune Response
Regulation Of Leukocyte Migration
Humoral Immune Response
Chromosome Segregation
Localization

Methylation
Cytokine Production
Reverse Transcription
Sensitization
Cell Cycle
Cell Differentiation
Micturition

PTMs

Phosphorylation

Methylation

Research Areas

Cell Cycle and Replication

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ARHGEF1

References

PMID: 8810315 by Hart M.J., et al. Identification of a novel guanine nucleotide exchange factor for the rho GTPase.

PMID: 9135076 by Aasheim H.-C., et al. Characterization, expression and chromosomal localization of a human gene homologous to the mouse Lsc oncogene, with strongest expression in hematopoetic tissues.