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ARID1B Antibodies
AND ARID1B ELISA kits, ARID1B Proteins
Many biological assays use antibodies to detect ARID1B, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ARID1B in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ARID1B antibodies...
Designing an IHC experiment for ARID1B? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the ARID1B IHC GuideARID1B Infographic by Boster Bio
All ARID1B Products
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Specificity
Applications
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ARID1B Overview
Facts about AT-rich interactive domain-containing protein 1B.
AT-rich interactive domain-containing protein 1B (ARID1B)
Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic actions, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Belongs to the neural progenitors- specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex).
During neural development a change from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes.
Gene Information
| Human | |
|---|---|
| Gene Name: | ARID1B |
| Uniprot: | Q8NFD5 |
| Entrez: | 57492 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
6A3-5; ARID domain-containing protein 1B; AT rich interactive domain 1B (SWI1-like); BAF250B; BRG1-associated factor 250b; BRG1-binding protein ELD/OSA1; BRG1-binding protein hELD/OSA1; BRIGHT; DAN15P250R; ELD (eyelid)/OSA protein; ELD/OSA1; hOsa2; JPUT1; KDM5B; KIAA1235AT-rich interactive domain-containing protein 1B; Osa homolog 2; OSA2; p250R; PLU1; RBBP2H1A
Molecular Weight
Mass (kDA):
236.123 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 6q25.3 |
| Sequence: | 6; NC_000006.12 (156776026..157210779) |
Tissue Specificity
Widely expressed with high levels in heart, skeletal muscle and kidney.
Subcellular Localizations
Nucleus.
Diseases
- Neoplasms
- Malignant Neoplasms
- Carcinoma
- Haploinsufficiency
- Mammary Neoplasms
- Congenital Absence
- Congenital Abnormality
- Carcinogenesis
- Nervousness
- Pancreatic Neoplasm
- Congenital Hand Deformities
- Cell Transformation, Neoplastic
Interacting Proteins
- SMARCA2
- SMARCA4
Pathways
- Chromatin Remodeling
- Cell Cycle
- Localization
- Cell Cycle Arrest
- Cell Proliferation
- Atp-dependent Chromatin Remodeling
- Prepulse Inhibition
- Mitosis
- Brain Development
- Dna Repair
- Glomerular Filtration
- Senescence
- System Development
PTMs
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ARID1B
bosterbio.com/bosterbio-gene-info-cards/ARID1B
References
PMID: 11734557 by Kato H., et al. SYT associates with human SNF/SWI complexes and the C-terminal region of its fusion partner SSX1 targets histones.
PMID: 9804814 by Mangel L., et al. New 5'-(CGG)-3' repeats in the human genome.