Arylsulfatase A Antibodies

Arylsulfatase A (ARSA)

Hydrolyzes cerebroside sulfate. .

Gene Information

Human
Gene Name:	ARSA
Uniprot:	P15289
Entrez:	410

Family

Belongs to:
sulfatase family

Alternative Names

ARSA; Arylsulfatase A; ASA; Cerebroside 3-sulfatase; Cerebroside-sulfatase; EC 3.1.6; EC 3.1.6.8; MLD

Molecular Weight

Mass (kDA):
53.588 kDA

Genomic Context

Human
Location:	22q13.33
Sequence:	22; NC_000022.11 (50622754..50628152, complement)

Subcellular Localizations

Endoplasmic reticulum. Lysosome.

Diseases

• Leukodystrophy, Metachromatic
• Leukodystrophy
• Nervousness
• Storage Disease
• Lysosomal Storage Diseases
• Deficiency Of Arylsulfatase
• Demyelination
• Aberrant Subclavian Artery
• Muscle Hypotonia
• Neoplasms
• Overgrowth Bacterial
• Hereditary Diseases

• Arylsulfatase A Deficiency
• Aneurysm
• Chromosomal Translocation
• Neurodegenerative Disorders
• Malignant Neoplasms
• Congenital Heart Defects

Interacting Proteins

• RHOXF2
• TRIP13

Pathways

• Transport
• Localization
• Secretion
• Proteolysis
• Transposition
• Arsenite Transport
• Interphase
• Sulfation
• Methylation
• Cell Growth
• Excretion
• Fertilization
• Sperm-egg Recognition

• Reflex
• Spermatogenesis
• Cellular Ion Homeostasis
• Cell Division
• Translation
• Nitrogen Fixation
• Meiosis

PTMs

• Cleavage

• Glycosylation

• Nitration

Research Areas

• Lipid and Metabolism

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ARSA

Boster Bio - Best Uses Of The ARSA Marker

The ARSA Marker is an ideal biomedical marker, which is why Boster offers highly validated monoclonal antibodies. It is an essential part of immunohistochemistry and is often used in the detection of gliomas. Boster also offers IHC-optimized detection systems. All products are guaranteed quality. Educators are allowed to share the resources on their websites, as long as they provide a citation or link to the Boster Bio website.

Boster offers highly validated monoclonal antibodies

High-quality monoclonal antibodies to the ARSA marker are an important tool in the diagnostics process. The antibodies have been validated against a wide range of samples and reagents. The company's histology laboratory provides high-quality immunogens and detection systems optimized for IHC. Customers may request validation images and procedures upon request. In addition, the company's Picoband(tm) technology is backed by insights into the optimal immunogen design and reagent.

Anti-CD8a monoclonal antibody from Boster Bio reacts with human CD8a (CD8a) and recognizes the CD8 alpha antigen. This antibody is flow tested and can be stored at 4degC for up to one year. It is also freeze-dried for future use. For a higher yield of positive results, anti-CD8a monoclonal antibodies can also be used in the detection of HSV infection.

The company's monoclonal antibodies have high affinity and sensitivity, and can be used for a variety of diagnostic applications. The company also sells highly validated polyclonal antibodies and custom peptides for various areas of research. The company's website includes customer reviews and specific protocols for using these antibodies. While selecting an antibody, you should always consider its intended use.

The ASFV is a hemorrhagic viral disease that affects domestic pigs. Until now, there is no safe vaccine against ASFV, and early diagnosis is essential in eradication. Developing highly validated monoclonal antibodies against the ASFV marker is a critical step in the process. The company's anti-CD8 MAb has demonstrated significant antiviral activity against macaques in animal studies. It significantly reduced the viral load in three macaques, compared to a control group. In addition to reducing the viral load, the treatment also reduced the CD4 cell count in macaque 565Z. However, the macaque 565Z maintained its low peripheral T cell count.

Various antibodies have been produced from various sources, including pig and chicken. The company's extensive product line includes ELISA kits, specialty research products, and custom antibodies. Biosensis, for example, manufactures highly validated monoclonal antibodies to the ARSA marker. The company also offers various reagents, including anti-IgY agarose. The company also offers a comprehensive range of anti-IgG, anti-IgY, and RNAi reagents.

Highly validated secondary antibodies

If you need high-quality ELISA kits and antibodies, you should look into Boster Bio. This company has more than 25 years of experience and produces high-quality antibodies and ELISA kits. Boster Bio offers the most value for research scientists worldwide. Here are just a few of its many products:

The Boster Bio high-validated secondary antibodies are manufactured in its own facilities. The company conducts a systematic manual survey of over 60000 randomly selected publications to compile its list of the highest-quality suppliers. Each supplier's list includes the five most cited products and is updated regularly to reflect the most recent data. The quality of Boster's high-validated secondary antibodies is unrivaled in the industry.

Among the high-validated secondary antibodies from Boster Bio, the peroxidase-affinipure goat anti-rabbit IgG (H+L) is the most cited. The fluorescein-affinipure donkey anti-rabbit IgG is another highly-validated product. Its total number of citations stands at 32936. It is important to note that Boster Bio highly validated secondary antibodies are suitable for research in both routine diagnostic laboratories and basic science laboratories.

Another highly-validated secondary antibody from Boster Bio is the anti-human immunoglobulin MHC antibody. It is also useful for immunostaining in the diagnosis of various diseases. This antibody is highly sensitive and specific, allowing researchers to quickly identify abnormal tissues. Its high-quality is ensured by the company's commitment to quality. The company has a dedicated team of scientists who are skilled in immunoassay development and validation.

IHC-optimized detection systems

The development of Boster Bio ARSA markers for IHC-optimized detection systems has enabled the development of a high-specificity, highly sensitive immunohistochemistry marker. The sensitivity of the IHC staining depends on the type of tissue, the amount of expression of the target antigen, and the detection method used. The choice of a specific system depends on the desired sensitivity and the time and cost associated with it.

Depending on the type of detection system used, a lower concentration of the primary antibody may be required. For instance, polymer-based detection systems require a lower concentration. High-concentration reagents may increase background staining. The Boster Bio ARSA marker for IHC-optimized detection systems uses a preformed avidin-biotin-peroxidase complex as the detection layer.

Another option is the polymer-enhanced two-step IHC detection system. EnVision contains secondary antimouse or rabbit Ig antibodies that have high tissue-binding capabilities. The EnVision system combines up to 20 secondary antibodies and nearly 100 peroxidase molecules. It is also very useful in emergencies, such as when the primary antibodies can't be detected.

One of the major advantages of the enzyme-antienzyme method is that it doesn't require chemical conjugation, and the number of enzyme molecules per antigenic site is much higher. The PAP method is particularly sensitive, with a sensitivity 100-1000 fold higher than the indirect method. Its triple-level detection is also highly suitable for cell IHC. It's not the only option for high-sensitivity IHC, as there are many other methods for assessing the sensitivity of a molecular marker.

Guaranteed quality

Boster Bio offers an extensive array of secondary antibodies and isotype controls optimized for IHC. They also provide a comprehensive guide with questions and answers on various topics including negative controls, sample preparation, and screening. For a thorough understanding of PCR, they recommend using the PCR expert guide, which includes a critical review of PCR principles, an all-in-one FAQ, and optimized protocols.