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- Table of Contents
ASH2L Antibodies
AND ASH2L ELISA kits, ASH2L Proteins
Many biological assays use antibodies to detect ASH2L, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ASH2L in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ASH2L antibodies...
Designing an IHC experiment for ASH2L? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the ASH2L IHC GuideASH2L Infographic by Boster Bio
All ASH2L Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A06129-1
100 µg/vial
Cat # A06129-1
100 µg/vial
ASH2L Overview
Facts about Set1/Ash2 histone methyltransferase complex subunit ASH2.
Set1/Ash2 histone methyltransferase complex subunit ASH2 (ASH2L)
Component of the Set1/Ash2 histone methyltransferase (HMT) complex, a complex that specifically methylates'Lys-4' of histone H3, but not if the neighboring'Lys-9' residue is already methylated. Included in the MLL1/MLL complex it is involved in methylation and dimethylation in'Lys-4' of histone H3.
May function as a transcriptional regulator. May play a role in hematopoiesis.
Gene Information
| Human | |
|---|---|
| Gene Name: | ASH2L |
| Uniprot: | Q9UBL3 |
| Entrez: | 9070 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
ash2 (absent, small, or homeotic)-like (Drosophila); ASH2; ASH2L1ash2 (absent, small, or homeotic, Drosophila, homolog)-like; ASH2L2ASH2-like protein; Bre2; set1/Ash2 histone methyltransferase complex subunit ASH2
Molecular Weight
Mass (kDA):
68.723 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 8p11.23 |
| Sequence: | 8; NC_000008.11 (38104965..38140080) |
Tissue Specificity
Ubiquitously expressed. Predominantly expressed in adult heart and testis and fetal lung and liver, with barely detectable expression in adult lung, liver, kidney, prostate, and peripheral leukocytes.
Subcellular Localizations
Nucleus.
Diseases
- Leukemia
- Neoplasms
- Multiple Endocrine Neoplasia Type 1
- Malignant Neoplasms
- Endocrine Gland Neoplasms
- Digeorge Syndrome
- Abnormal Degeneration
- Cell Transformation, Neoplastic
- Multiple Endocrine Neoplasia
- Cholangiocarcinoma
- Charge Syndrome
- Bile Duct Neoplasms
- Neuromuscular Diseases
Interacting Proteins
- AKAP8
- AR
- CHD8
- DPY30
- EP300
- HCFC1
- KMT2A
- KMT2B
- KMT2C
- KMT2D
Pathways
- Methylation
- Histone Modification
- Chromatin Organization
- Gene Silencing
- Regulation Of Gene Expression
- Cell Division
- Cell Cycle
- Histone Methylation
- Localization
- Regeneration
- Rna Interference
- Transport
- Atp-dependent Chromatin Remodeling
PTMs
- Methylation
- Phosphorylation
- Acetylation
Research Areas
- DNA Repair
- Transcription Factors and Regulators
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ASH2L
bosterbio.com/bosterbio-gene-info-cards/ASH2L
References
PMID: 11466562 by Wang J., et al. ASH2L: alternative splicing and downregulation during induced megakaryocytic differentiation of multipotential leukemia cell lines.
PMID: 10393421 by Ikegawa S., et al. Cloning and characterization of ASH2L and ash2l, human and mouse homologs of the Drosophila ash2 gene.