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- Table of Contents
ASPH Antibodies
AND ASPH ELISA kits, ASPH Proteins
Many biological assays use antibodies to detect ASPH, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ASPH in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ASPH antibodies...
Designing a Western blot for ASPH? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the ASPH Western Blot GuideDesigning an IHC experiment for ASPH? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the ASPH IHC GuideASPH Infographic by Boster Bio
All ASPH Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
Flow Cytometry, IHC, ICC, WB
$370
Cat # PB9478
100 μg/vial
Cat # PB9478
100 μg/vial
Human
$960
Cat # LS000444
20 µg, 100 µg
Cat # LS000444
20 µg, 100 µg
ASPH Overview
Facts about Aspartyl/asparaginyl beta-hydroxylase.
Aspartyl/asparaginyl beta-hydroxylase (ASPH)
Isoform 1: specifically hydroxylates an Asp or Asn residue in certain epidermal growth factor-like (EGF) domains of a number of proteins. .
Gene Information
| Human | |
|---|---|
| Gene Name: | ASPH |
| Uniprot: | Q12797 |
| Entrez: | 444 |
Family
| Belongs to: |
|---|
| aspartyl/asparaginyl beta-hydroxylase family |
Alternative Names
AAH; ASP beta-hydroxylase; aspartate beta-hydroxylaseA beta H-J-J; aspartyl/asparaginyl-beta-hydroxylase; BAH; cardiac junctin; CASQ2BP1; EC 1.14.11.16; HAAHaspartyl/asparaginyl beta-hydroxylase; humbug; JCTN; junctate; junctin; Peptide-aspartate beta-dioxygenase
Molecular Weight
Mass (kDA):
85.863 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 8q12.3 |
| Sequence: | 8; NC_000008.11 (61500556..61714640, complement) |
Tissue Specificity
Isoform 1 is detected in all tissues tested. Isoform 8 is mainly expressed in pancreas, heart, brain, kidney and liver. Isoform 8 is expressed in kidney (at protein level).
Subcellular Localizations
[Isoform 1]: Endoplasmic reticulum membrane; Single-pass type II membrane protein.; [Isoform 4]: Sarcoplasmic reticulum membrane; Single-pass type II membrane protein.; [Isoform 8]: Endoplasmic reticulum membrane; Single-pass type II membrane protein.
Diseases
- Cardiac Arrhythmia
- Hypertrophy
- Heart Failure
- Neoplasms
- Tachycardia, Ventricular
- Endometriosis, Site Unspecified
- Neoplasm Metastasis
- Cardiac Hypertrophy
- Malignant Neoplasms
- Polymorphic Ventricular Tachycardia
- Carcinoma
- Heart Diseases
- Cholangiocarcinoma
Interacting Proteins
- ASNA1
Pathways
- Localization
- Cell Migration
- Regulation Of Muscle Contraction
- Transport
- Fertilization
- Dna Methylation
- Glycosylation
- Immune Response
- Muscle Contraction
- Methylation
- Drug Resistance
- Muscle Hypertrophy
- Translation
PTMs
- Phosphorylation
- Hydroxylation
Research Areas
- Cancer
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ASPH
bosterbio.com/bosterbio-gene-info-cards/ASPH
References
PMID: 7821814 by Korioth F., et al. Cloning and characterization of the human gene encoding aspartyl beta-hydroxylase.
PMID: 8823296 by Lavaissiere L., et al. Overexpression of human aspartyl(asparaginyl)beta-hydroxylase in hepatocellular carcinoma and cholangiocarcinoma.