ASPH Antibodies

Aspartyl/asparaginyl beta-hydroxylase (ASPH)

Isoform 1: specifically hydroxylates an Asp or Asn residue in certain epidermal growth factor-like (EGF) domains of a number of proteins. .

Gene Information

Human
Gene Name:	ASPH
Uniprot:	Q12797
Entrez:	444

Family

Belongs to:
aspartyl/asparaginyl beta-hydroxylase family

Alternative Names

AAH; ASP beta-hydroxylase; aspartate beta-hydroxylaseA beta H-J-J; aspartyl/asparaginyl-beta-hydroxylase; BAH; cardiac junctin; CASQ2BP1; EC 1.14.11.16; HAAHaspartyl/asparaginyl beta-hydroxylase; humbug; JCTN; junctate; junctin; Peptide-aspartate beta-dioxygenase

Molecular Weight

Mass (kDA):
85.863 kDA

Genomic Context

Human
Location:	8q12.3
Sequence:	8; NC_000008.11 (61500556..61714640, complement)

Tissue Specificity

Isoform 1 is detected in all tissues tested. Isoform 8 is mainly expressed in pancreas, heart, brain, kidney and liver. Isoform 8 is expressed in kidney (at protein level).

Subcellular Localizations

[Isoform 1]: Endoplasmic reticulum membrane; Single-pass type II membrane protein.; [Isoform 4]: Sarcoplasmic reticulum membrane; Single-pass type II membrane protein.; [Isoform 8]: Endoplasmic reticulum membrane; Single-pass type II membrane protein.

Diseases

• Cardiac Arrhythmia
• Hypertrophy
• Heart Failure
• Neoplasms
• Tachycardia, Ventricular
• Endometriosis, Site Unspecified
• Neoplasm Metastasis
• Cardiac Hypertrophy
• Malignant Neoplasms
• Polymorphic Ventricular Tachycardia
• Carcinoma
• Heart Diseases
• Cholangiocarcinoma

• Hemorrhage
• Sudden Death
• Liver Carcinoma
• Malignant Paraganglionic Neoplasm
• Cataract
• Cell Invasion
• Atrial Fibrillation

Interacting Proteins

• ASNA1

Pathways

• Localization
• Cell Migration
• Regulation Of Muscle Contraction
• Transport
• Fertilization
• Dna Methylation
• Glycosylation
• Immune Response
• Muscle Contraction
• Methylation
• Drug Resistance
• Muscle Hypertrophy
• Translation

• Acrosome Reaction
• Cell Motility
• Cell Differentiation
• Pathogenesis
• Eye Development
• Rna Interference
• Secretion

PTMs

• Phosphorylation
• Hydroxylation

• Glycosylation
• Methylation

Research Areas

• Cancer

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ASPH

Boster Bio - Best Uses Of The ASPH Marker

This bio will give you a glimpse into Steven Boster's current research and his Histology work. You will also find information about his future plans. The ASPH website contains a complete biography of Boster. Below are the most used ASPH markers. Additionally, you can find information about Boster's other services such as enzymes, antibodies and reagents.

Histology

Steven Xia founded Boster Bio. The company specializes in high-specificity and high-sensitivity ELISA kit and anticuerpos for western blotting and immunohistochemistry. The company has more than 23,000 publications citing their products. Its anticuerpos are approved for ELISA and citometry applications, as well as WB/IHC. In addition to high-specificity, high-affinity ELISA kits, Boster offers custom services and BeNeLux deliveries.

Immunohistochemistry is a special way to stain cells to detect antigens and haptens. Boster Bio offers IHC-ready antibodies as well as high-sensitivity ELISA kits for use in cell and tissue immunohistochemistry. Its highly skilled services and over 14,000 publications have earned the trust of scientists around world. Boster Bio products are backed by a quality guarantee.

Steven Xia was the founder of Boster Bio. Since 1993, they have been developing and manufacturing high-specific antibodies and ELISA kit kits. They are highly skilled in immunohistochemistry, molecular biology, and have more than 12,000 antibodies to their credit. Boster Bio also performs multiplex IHC screenings and data confirmation. Boster Bio also archives their IHC results in record-breaking time at affordable prices. Over 5,000 publications have been published and more than 3,000 papers have been created based on IHC results.

Suo You Bster Kang Ti is a Chinese term meaning "histology". He is an integral part of biomedical research. He helps scientists understand the anatomy and function of cells. Histological methods allow doctors to identify cancerous cells in the body. The study of tumors can help doctors diagnose cancer patients more accurately. The Boster Bio Association offers information on histology. They will give you a reference guide for further reading.

Current research

The ASPH marker in cancer is an important biomarker. Upregulation results in the enzymatic alteration of Notch receptors, which activate Notch signaling. It is associated with interactions with ADAM 10/17, a protein that stabilizes the Notch receptor complex and enhances S2 cleavage. This activates target genes, including those that are associated with cell proliferation, invasion, and microvascular invade. This supports tumor growth.

Numerous studies have shown that ASPH expression is linked to the development of malignant cell lines. One study revealed that ASPH interacts wit GSK-3b. This multifunctional kinase plays a role in glycogen metabolism as well as cell division and fate determination. Inhibiting GSK-3b might lead to tumorigenesis. Inhibiting ASPH expression has also been shown to work in a few forms of cancer. In addition, Huang et al. Huang et al. reported that ASPH binds directly to retinoblastoma. This indicates that ASPH contributes to tumorigenesis.

Recent studies have demonstrated that ASPH hydroxylase activity is associated with invasiveness and metastatic potential of HCC. Studies in the past have shown that ASPH activity regulates EMT pathways. This pathway could be controlled by ASPH activity through interaction with vimentin. However, further research is needed in order to fully understand ASPH's contribution to HCC. So, current research on the ASPH Marker continues to identify new targets in the treatment of cancer.

ASPH expression can be assessed using immuno-staining. These studies have been problematic due to the fact that the antibodies used in the test were not sufficiently specific for ASPH, which is the enzyme that is affected. The H679A-mutant showed a lesser aKG consumption than WT. The mutant also showed a 76% decrease in hydroxylase activity. ASPH is an important biomarker for cancer immunotherapy.

The ASPH gene undergoes extensive alternative splicing. The full-length ASPH gene is encoded in the 5' untranslated region. ASPH includes a catalytic-C-terminal domain. The cbEGF-like domains regulate cell motility and hydroxylation. It is also an essential determinant for EMT signalling.

Future plans

The core competencies of public health practice were first defined by the ASPH in 2004. These competencies outline the course work that is required to develop them. It is essential that the ASPH Marker changes with public health practice. Collaboration between academic and practice communities is necessary to achieve this goal. The core competencies required for public health practice do not have to be mutually exclusive. Both sets of competencies emphasize the need for continuous improvement and assessment.

The MPH program's core competencies are used to assess students' proficiency in the core competency of public healthcare. This framework is valid, but it does not make public health practitioners the only designation that can be earned. However, the ASPH core competencies offer a wider view of MPH degree programs. They emphasize the development of skills, knowledge, and attitudes outside the student's major field. It is unlikely any student will be able master all of the competencies within a single year.