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- Table of Contents
ATF5 Antibodies
AND ATF5 ELISA kits, ATF5 Proteins
Many biological assays use antibodies to detect ATF5, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ATF5 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ATF5 antibodies...
Designing an IHC experiment for ATF5? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the ATF5 IHC GuideATF5 Infographic by Boster Bio
All ATF5 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
IP, IF, IHC, ICC, WB
$370
Cat # M02792
100 μl
Cat # M02792
100 μl
Human, Mouse, Rat
ELISA, Flow Cytometry, WB
$370
Cat # A02792-1
100 μg/vial
Cat # A02792-1
100 μg/vial
Human, Mouse, Rat
ELISA
$480
Cat # EKC1043
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1043
1 kit, containing one 96-well plate and all necessary reagents
ATF5 Overview
Facts about Cyclic AMP-dependent transcription factor ATF-5.
Cyclic AMP-dependent transcription factor ATF-5 (ATF5)
Transcription factor that either stimulates or represses gene transcription through binding of distinct DNA regulatory elements such as cAMP response element (CRE) (consensus: 5'- GTGACGT[AC][AG]-3'), ATF5-specific response element (ARE) (consensus: 5'-C[CT]TCT[CT]CCTT[AT]-3') but also the amino acid response element (AARE), present in many viral and cellular promoters. Critically involved, often in a mobile type-dependent fashion, in cell survival, proliferation, and differentiation (PubMed:10373550, PubMed:15358120, PubMed:21212266, PubMed:20654631).
Important regulator of the cerebral cortex formation, functions in cerebral cortical neuroprogenitor cells to maintain proliferation and to block differentiation into neurons. Must be down-regulated in order for these cells to leave the cycle and differentiate (By similarity).
Gene Information
| Human | |
|---|---|
| Gene Name: | ATF5 |
| Uniprot: | Q9Y2D1 |
| Entrez: | 22809 |
Family
| Belongs to: |
|---|
| bZIP family |
Alternative Names
activating transcription factor 5FLJ34666; ATFXHMFN0395; cAMP-dependent transcription factor ATF-5; cyclic AMP-dependent transcription factor ATF-5; Transcription factor ATFx
Molecular Weight
Mass (kDA):
30.674 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 19q13.33 |
| Sequence: | 19; NC_000019.10 (49928702..49933936) |
Tissue Specificity
Widely expressed with higher expression levels in liver.
Subcellular Localizations
Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Actively transported to the centrosome and accumulated in the pericentriolar material (PCM) during G1 to M phase via a microtubule-dependent mechanism. During late telophase and cytokinesis, translocates from the centrosome to the midbody.
Diseases
- Neoplasms
- Malignant Neoplasms
- Glioblastoma
- Glioma
- Carcinoma
- Leukemia
- Malignant Paraganglionic Neoplasm
- Liver Carcinoma
- Brain Neoplasms
- Malignant Neoplasm Of Breast
- Endoplasmic Reticulum Stress
- Malignant Glioma
Interacting Proteins
- CEBPG
- DISC1
Pathways
- Cell Differentiation
- Cell Death
- Translation
- Cell Cycle
- Cell Proliferation
- Localization
- Brain Development
- Induction Of Apoptosis
- Drug Resistance
- Pathogenesis
- Freezing Tolerance
- Secretion
- Cell Adhesion
PTMs
- Phosphorylation
- Methylation
- Cleavage
Research Areas
- Cell Cycle and Replication
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ATF5
bosterbio.com/bosterbio-gene-info-cards/ATF5
References
PMID: 11087824 by White J.H., et al. The GABAB receptor interacts directly with the related transcription factors CREB2 and ATFx.
PMID: 15221005 by Yamada S., et al. Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas.