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Atrophin-1 Antibodies
AND ATN1 ELISA kits, Atrophin-1 Proteins
Many biological assays use antibodies to detect Atrophin-1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Atrophin-1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Atrophin-1 antibodies...
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ATN1 Overview
Facts about Atrophin-1.
Atrophin-1 (ATN1)
Transcriptional corepressor. Recruits NR2E1 to repress transcription.
Promotes vascular smooth cell (VSMC) migration and orientation (By similarity). Corepressor of MTG8 transcriptional repression.
Gene Information
| Human | |
|---|---|
| Gene Name: | ATN1 |
| Uniprot: | P54259 |
| Entrez: | 1822 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
ATN1; atrophin 1; atrophin-1; B37; D12S755E; dentatorubral-pallidoluysian atrophy (atrophin-1); Dentatorubral-pallidoluysian atrophy protein; DRPLA; DRPLANOD; HRS; NOD
Molecular Weight
Mass (kDA):
125.414 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 12p13.31 |
| Sequence: | 12; NC_000012.12 (6924459..6942321) |
Tissue Specificity
Widely expressed in various tissues including heart, lung, kidney, ovary, testis, prostate, placenta, skeletal Low levels in the liver, thymus and leukocytes. In the adult brain, broadly expressed in amygdala, caudate nucleus, corpus callosum, hippocampus, hypothalamus, substantia nigra, subthalamic nucleus, and thalamus. High levels in fetal tissues, especially brain.
Subcellular Localizations
Nucleus. Cytoplasm, perinuclear region. Cell junction. Shuttles between nucleus and cytoplasm. Colocalizes with FAT1 in the perinuclear area, at cell-cell junctions and leading edges of cells (By similarity). Colocalizes with MTG8 in discrete nuclear dots. Proteolytic fragment F1 appears to remain in nucleus. Fragment F2 is exported into the cytoplasm. Fragment F2 from mutant sequences with longer poly-Gln (polyQ) tracts are additionally located to the cytoplasmic membrane and to certain organelles.
Diseases
- Atrophy
- Ataxia
- Trinucleotide Repeat Expansion
- Dentatorubral-pallidoluysian Atrophy
- Malignant Neoplasms
- Neoplasms
- Ataxia, Spinocerebellar
- Neurodegenerative Disorders
- Myoclonic Epilepsies, Progressive
- Dementia
- Nervousness
- Nerve Degeneration
Interacting Proteins
- EFEMP1
- EFEMP2
- PLEKHA5
- PSME3
- RBFOX1
- RERE
- TRIP6
- WDR5
Pathways
- Pathogenesis
- Localization
- Regeneration
- Cell Proliferation
- Tissue Morphogenesis
- Cell Cycle
- Brain Development
- Tube Formation
PTMs
Research Areas
- Cancer
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ATN1
bosterbio.com/bosterbio-gene-info-cards/ATN1
References
PMID: 7842016 by Nagafuchi S., et al. Structure and expression of the gene responsible for the triplet repeat disorder, dentatorubral and pallidoluysian atrophy (DRPLA).
PMID: 7485154 by Onodera O., et al. Molecular cloning of a full-length cDNA for dentatorubral- pallidoluysian atrophy and regional expressions of the expanded alleles in the CNS.