Desmocollin-1 Antibodies

AND DSC1 ELISA kits, Desmocollin-1 Proteins

Many biological assays use antibodies to detect Desmocollin-1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Desmocollin-1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Desmocollin-1 antibodies...

We validate the specificity of these antibodies to Desmocollin-1 by testing them on tissues known to express DSC1 positively and negatively. Browse below to find the DSC1 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Designing a Western blot for Desmocollin-1? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.

Open the DSC1 Western Blot Guide

DSC1 Infographic by Boster Bio

All DSC1 Products

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Product

Figures

Specificity

Applications

Price

Anti-Desmocollin 1 Rabbit Monoclonal Antibody

Western blot analysis of DSC1 using anti-DSC1 antibody (M03478)

Human, Mouse, Rat

$370
Cat # M03478
100 µl/vial

Desmocollin 1 (DSC1) (NM_024421) Human Over-expression Lysate

Human

$960
Cat # LS001823
20 µg, 100 µg

Human DSCR1 isoform b Recombinant Protein

SDS-PAGE

$265
Cat # PROTP53805
Starting from 20ug

DSC1 Overview

Facts about Desmocollin-1.

DSC1 3D structure. Source: alphafold

Desmocollin-1 (DSC1)

Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.

May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells which express different isoforms. Connected to the keratinization of epithelial tissues.

Gene Information

Human
Gene Name:	DSC1
Uniprot:	Q08554
Entrez:	1823

Family

Belongs to:

No superfamily

Alternative Names

cadherin family member 1; CDHF1; desmocollin 1; Desmocollin1; Desmocollin-1; desmosomal glycoprotein 2/3; DG2/DG3 ; DG2/DG3; DSC1

Molecular Weight

Mass (kDA):
99.987 kDA

Genomic Context


Human

Location:	18q12.1
Sequence:	18; NC_000018.10 (31129236..31162856, complement)

Tissue Specificity

Strongly expressed in epidermis, less in lymph node and tongue.

Subcellular Localizations

Cell membrane; Single-pass type I membrane protein. Cell junction, desmosome.

Diseases

Tissue Adhesions
Dermatologic Disorders
Subcorneal Pustular Dermatosis
Neoplasms
Autoimmune Reaction
Pemphigus Foliaceus
Dental Plaque
Malignant Neoplasms
Bulla
Carcinoma
Neoplasm Metastasis

Ulcer
Ichthyosis Linearis Circumflexa
Adenocarcinoma
Acantholysis
Malignant Paraganglionic Neoplasm
Skin Diseases, Vesiculobullous

Pathways

Cell Cycle
Dna Replication
S Phase
Cell Adhesion
Pathogenesis
Keratinocyte Differentiation
Mitotic Cell Cycle
Cell-cell Adhesion
Dna Replication Checkpoint
Cell Proliferation
Proteolysis
Meiosis
G1 Phase

Localization
Cell Division
Keratinization
Sporulation
Desmosome Assembly
Demethylation
Endosperm Development

PTMs

Phosphorylation
Cleavage
Methylation

Demethylation
Ribosylation
Deglycosylation

Ubiquitination

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/DSC1

References

PMID: 8507556 by Theis D.G., et al. Differential synthesis of type 1 and type 2 desmocollin mRNAs in human stratified epithelia.

PMID: 8288219 by King I.A., et al. Cloning of the cDNA (DSC1) coding for human type 1 desmocollin and its assignment to chromosome 18.