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- Table of Contents
Ataxin-2 Antibodies
AND ATXN2 ELISA kits, Ataxin-2 Proteins
Many biological assays use antibodies to detect Ataxin-2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Ataxin-2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Ataxin-2 antibodies...
Designing a Western blot for Ataxin-2? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the ATXN2 Western Blot GuideATXN2 Infographic by Boster Bio
All ATXN2 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # PA2098
100 μg/vial
Cat # PA2098
100 μg/vial
Human
$960
Cat # LS011273
20 µg, 100 µg
Cat # LS011273
20 µg, 100 µg
ATXN2 Overview
Facts about Ataxin-2.
Ataxin-2 (ATXN2)
Involved in EGFR trafficking, acting as negative regulator of endocytic EGFR internalization at the plasma membrane. .
Gene Information
| Human | |
|---|---|
| Gene Name: | ATXN2 |
| Uniprot: | Q99700 |
| Entrez: | 6311 |
Family
| Belongs to: |
|---|
| ataxin-2 family |
Alternative Names
ataxin 2; ataxin 2); ataxin-2; ATX2spinocerebellar ataxia 2 (olivopontocerebellar ataxia 2, autosomal dominant; SCA2FLJ46772; Spinocerebellar ataxia type 2 protein; TNRC13; trinucleotide repeat containing 13; Trinucleotide repeat-containing gene 13 protein
Molecular Weight
Mass (kDA):
140.283 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 12q24.12 |
| Sequence: | 12; NC_000012.12 (111452214..111599676, complement) |
Tissue Specificity
Expressed in the brain, heart, liver, skeletal muscle, pancreas and placenta. Isoform 1 is predominant in the brain and spinal cord. Isoform 4 is more abundant in the cerebellum. In the brain, broadly expressed in the amygdala, caudate nucleus, corpus callosum, hippocampus, hypothalamus, substantia nigra, subthalamic nucleus and thalamus.
Subcellular Localizations
Cytoplasm.
Diseases
- Ataxia
- Ataxia, Spinocerebellar
- Spinocerebellar Ataxia Type 2
- Sclerosis
- Primary Lateral Sclerosis
- Amyotrophic Lateral Sclerosis
- Trinucleotide Repeat Expansion
- Neurodegenerative Disorders
- Parkinson Disease
- Secondary Parkinson Disease
- Cerebellar Ataxia
Interacting Proteins
- ATXN1
- DDX6
- G3BP1
- PABPC1
- SH3GL2
- SH3GL3
- TARDBP
Pathways
- Pathogenesis
- Glomerular Filtration
- Aging
- Endocytosis
- Transport
- Dna Methylation
- Dna Repair
- Nuclear Export
- Localization
- Methylation
- Translation
PTMs
- Phosphorylation
Research Areas
- Cellular Markers
- Hematopoietic Stem Cell Markers
- Stem Cell Markers
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ATXN2
bosterbio.com/bosterbio-gene-info-cards/ATXN2
References
PMID: 8896555 by Pulst S.-M., et al. Moderate expansion of a normally biallelic trinucleotide repeat in spinocerebellar ataxia type 2.
PMID: 8896556 by Sanpei K., et al. Identification of the spinocerebellar ataxia type 2 gene using a direct identification of repeat expansion and cloning technique, DIRECT.