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- Table of Contents
ABCG2 Antibodies
AND ABCG2 ELISA kits, ABCG2 Proteins
Many biological assays use antibodies to detect ABCG2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ABCG2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ABCG2 antibodies...
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ABCG2 Infographic by Boster Bio
All ABCG2 Products
Product
Figures
Specificity
Applications
Price
Anti-BCRP/ABCG2 Antibody Picoband®
6 Citations
Human, Mouse, Rat
ELISA, Flow Cytometry, IHC, WB
$370
Cat # A00457-2
100 μg/vial
Cat # A00457-2
100 μg/vial
ABCG2 Overview
Facts about Broad substrate specificity ATP-binding cassette transporter ABCG2.
Broad substrate specificity ATP-binding cassette transporter ABCG2 (ABCG2)
High-capacity urate exporter working in both renal and extrarenal urate excretion. Plays a role in porphyrin homeostasis as it is able to mediates the export of protoporhyrin IX (PPIX) both from mitochondria to cytosol and from cytosol to extracellular space, and cellular export of hemin, and heme.
Xenobiotic transporter that may play an important role in the exclusion of xenobiotics from the brain. Appears to play a significant role in the multidrug resistance phenotype of many cancer cell lines.
Gene Information
| Human | |
|---|---|
| Gene Name: | ABCG2 |
| Uniprot: | Q9UNQ0 |
| Entrez: | 9429 |
Family
| Belongs to: |
|---|
| ABC transporter superfamily |
Alternative Names
ABC transporter; ABC15; ABCG2; ABCP; ABCPMGC102821; ATP-binding cassette sub-family G member 2; ATP-binding cassette transporter G2; ATP-binding cassette, sub-family G (WHITE), member 2; BCRP; BCRP1; BCRPMRX; BMDP; Breast cancer resistance protein; CD338 antigen; CD338; CDw338; EST157481; mitoxantrone resistance protein; Mitoxantrone resistance-associated protein; MXR; MXRMXR1; placenta specific MDR protein; Placenta-specific ATP-binding cassette transporter
Molecular Weight
Mass (kDA):
72.314 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 4q22.1 |
| Sequence: | 4; NC_000004.12 (88090264..88231626, complement) |
Tissue Specificity
Highly expressed in placenta. Low expression in small intestine, liver and colon.
Subcellular Localizations
Cell membrane; Multi-pass membrane protein. Apical cell membrane; Multi-pass membrane protein. Mitochondrion membrane; Multi-pass membrane protein. Enriched in membrane lipid rafts.
Diseases
- Malignant Neoplasms
- Malignant Neoplasm Of Breast
- Neoplasms
- Mammary Neoplasms
- Carcinoma
- Leukemia
- Malignant Neoplasm Of Lung
- Lung Neoplasms
- Myeloid Leukemia
- Malignant Paraganglionic Neoplasm
- Neoplasm Metastasis
- Non-small Cell Lung Carcinoma
- Leukemia, Myelocytic, Acute
Interacting Proteins
- UBC
Pathways
- Transport
- Drug Resistance
- Excretion
- Localization
- Drug Transport
- Secretion
- Cell Proliferation
- Cell Cycle
- Regeneration
- Cell Growth
- Reverse Transcription
- Cell Death
- Intestinal Absorption
PTMs
- Phosphorylation
- Methylation
- Glycosylation
- Cleavage
- Demethylation
- Carboxylation
- Ubiquitination
- Reduction
- Acetylation
Research Areas
- ABC Transporters
- Cancer
- Cellular Markers
- Hematopoietic Stem Cell Markers
- Neuronal Cell Markers
- Stem Cell Markers
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ABCG2
bosterbio.com/bosterbio-gene-info-cards/ABCG2
References
PMID: 9850061 by Allikmets R., et al. A human placenta-specific ATP-binding cassette gene (ABCP) on chromosome 4q22 that is involved in multidrug resistance.
PMID: 9861027 by Doyle L.A., et al. A multidrug resistance transporter from human MCF-7 breast cancer cells.
10 Publications of Boster ABCG2 Antibodies & ELISA Kits
- PubMed ID: 10.3892/ol.2013.1103, Characterization of side population cells isolated from the gastric cancer cell ...
- PubMed ID: 10.3892/ijo.2014.2448, β-elemene inhibits stemness, promotes differentiation and impairs chemoresistan...
- PubMed ID: 10.1016/j.jep.2013.10.028, The mechanism of the opening of the blood–brain barrier by borneol: A pharmaco...
- PubMed ID: -, Panchamia, Shail. (2020). To Investigate The Impact Of Gut Bacteria On Efflux Tr...
- PubMed ID: 29399180, Characteristics of doxorubicin-selected multidrug-resistant human leukemia HL-60...
- PubMed ID: 26563263, Reversion of malignant phenotypes of human glioblastoma cells by ?-elemene throu...
- PubMed ID: 24175763, Wang Nn, Zhao Lj, Wu Ln, He Mf, Qu Jw, Zhao Yb, Zhao Wz, Li Js, Wang Jh. Asian P...
- PubMed ID: 21567100, Qiao B, Johnson Nw, Chen X, Li R, Tao Q, Gao J. Oncol Rep. 2011 Aug;26(2):455-61...
- PubMed ID: 22274587, Duan J, Mansour Hm, Zhang Y, Deng X, Chen Y, Wang J, Pan Y, Zhao J. Int J Pharm....
- PubMed ID: 23426065, Li R, Wu X, Wei H, Tian S. Oncol Lett. 2013 Mar;5(3):877-883. Epub 2013 Jan 2. C...
*More publications can be found for each product on its corresponding product page