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BMPR1B Antibodies
AND BMPR1B ELISA kits, BMPR1B Proteins
Many biological assays use antibodies to detect BMPR1B, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with BMPR1B in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop BMPR1B antibodies...
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BMPR1B Infographic by Boster Bio
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BMPR1B Overview
Facts about Bone morphogenetic protein receptor type-1B.
Bone morphogenetic protein receptor type-1B (BMPR1B)
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators.
Receptor for BMP7/OP-1 and GDF5. Positively regulates chondrocyte differentiation through GDF5 interaction.
Gene Information
| Human | |
|---|---|
| Gene Name: | BMPR1B |
| Uniprot: | O00238 |
| Entrez: | 658 |
Family
| Belongs to: |
|---|
| protein kinase superfamily |
Alternative Names
activin receptor-like kinase 6; ALK-6; ALK6CDw293; BMP type-1B receptor; BMPR1B; BMPR-1B; BMPRIB; BMPR-IB; bone morphogenetic protein receptor type-1B; bone morphogenetic protein receptor, type IB; CDw293 antigen; CDw293; EC 2.7.11; EC 2.7.11.30; serine/threonine receptor kinase
Molecular Weight
Mass (kDA):
56.93 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 4q22.3 |
| Sequence: | 4; NC_000004.12 (94757955..95158453) |
Subcellular Localizations
Cell membrane. Membrane; Single-pass type I membrane protein.
Diseases
- Malignant Neoplasms
- Neoplasms
- Malignant Neoplasm Of Breast
- Brachydactyly
- Mammary Neoplasms
- Nervousness
- Tumor Angiogenesis
- Brachydactyly, Type A2
- Carcinoma
- Malignant Neoplasm Of Prostate
- Limb Deformities, Congenital
- Neoplasm Metastasis
Interacting Proteins
- BMP2
- GDF5
Pathways
- Ovulation
- Cell Proliferation
- Osteoblast Differentiation
- Localization
- Cell Differentiation
- Pathogenesis
- Angiogenesis
- Regeneration
- Cell Growth
- Neurogenesis
- Cell Cycle
- Lung Development
- Ossification
PTMs
- Phosphorylation
- Cleavage
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/BMPR1B
bosterbio.com/bosterbio-gene-info-cards/BMPR1B
References
PMID: 9178898 by Ide H., et al. Cloning of human bone morphogenetic protein type IB receptor (BMPR- IB) and its expression in prostate cancer in comparison with other BMPRs.
PMID: 10051328 by Astroem A.-K., et al. Chromosomal localization of three human genes encoding bone morphogenetic protein receptors.