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- Table of Contents
BRF1 Antibodies
AND BRF1 ELISA kits, BRF1 Proteins
Many biological assays use antibodies to detect BRF1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with BRF1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop BRF1 antibodies...
Designing a Western blot for BRF1? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the BRF1 Western Blot GuideDesigning an IHC experiment for BRF1? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the BRF1 IHC GuideBRF1 Infographic by Boster Bio
All BRF1 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse
ELISA
$480
Cat # EKC1894
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1894
1 kit, containing one 96-well plate and all necessary reagents
Human, Mouse, Rat
ELISA
$480
Cat # EKC1568
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1568
1 kit, containing one 96-well plate and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC2329
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2329
1 kit, containing two 96-well plates and all necessary reagents
BRF1 Overview
Facts about Transcription factor IIIB 90 kDa subunit.
Transcription factor IIIB 90 kDa subunit (BRF1)
General activator of RNA polymerase which uses different TFIIIB complexes at distinct promoters. The isoform 1 is involved in the transcription of tRNA, adenovirus VA1, 7SL and 5S RNA.
Isoform 2 is necessary for transcription of the U6 promoter. .
Gene Information
| Human | |
|---|---|
| Gene Name: | BRF1 |
| Uniprot: | Q92994 |
| Entrez: | 2972 |
Family
| Belongs to: |
|---|
| TFIIB family |
Alternative Names
B-related factor 1; BRF1 homolog, subunit of RNA polymerase III transcription initiation factorIIIB (S. cerevisiae); BRF-1; BRFFLJ42674; general transcription factor IIIB, 90kD subunit; GTF3BTAFIII90; hBRFMGC105048; hTFIIIB90; TAF3B2; TAF3CB - related factor 1; TATA box binding protein (TBP)-associated factor 3C; TATA box binding protein (TBP)-associated factor, RNA polymerase III, GTF3Bsubunit 2; TATA box binding protein (TBP)-associated factor, RNA polymerase III, subunit 2; TATA box-binding protein-associated factor, RNA polymerase III, subunit 2; TBP - associated factor, RNA polymerase III
Molecular Weight
Mass (kDA):
73.84 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 14q32.33 |
| Sequence: | 14; NC_000014.9 (105209286..105315577, complement) |
Subcellular Localizations
Nucleus.
Diseases
- Neoplasms
- Malignant Neoplasms
- Retinoblastoma
- Cell Transformation, Neoplastic
- Metaplastic Cell Transformation
- Carcinoma
- Malignant Neoplasm Of Breast
- Mammary Neoplasms
- Malignant Tumor Of Cervix
- Physiological Stress
- Hypertrophy
- Colorectal Neoplasms
- Growth Arrest
Pathways
- Translation
- Cell Proliferation
- Localization
- Cell Growth
- Cell Cycle
- Hyperphosphorylation
- Cellular Senescence
- Regulation Of Gene Expression
- Snrna Transcription
- Cell Differentiation
- Trna Transcription
- Mitosis
- Senescence
PTMs
- Phosphorylation
- Dephosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/BRF1
bosterbio.com/bosterbio-gene-info-cards/BRF1
References
PMID: 7624363 by Wang Z., et al. Structure and function of a human transcription factor TFIIIB subunit that is evolutionarily conserved and contains both TFIIB- and high- mobility-group protein 2-related domains.
PMID: 8943358 by Mital R., et al. RNA polymerase III transcription from the human U6 and adenovirus type 2 VAI promoters has different requirements for human BRF, a subunit of human TFIIIB.