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- Table of Contents
C1QBP Antibodies
AND C1QBP ELISA kits, C1QBP Proteins
Many biological assays use antibodies to detect C1QBP, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with C1QBP in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop C1QBP antibodies...
Designing a Western blot for C1QBP? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the C1QBP Western Blot GuideDesigning an IHC experiment for C1QBP? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the C1QBP IHC GuideC1QBP Infographic by Boster Bio
All C1QBP Products
Product
Figures
Specificity
Applications
Price
Anti-GC1q R/C1QBP Antibody Picoband®
2 Citations
Human, Mouse, Rat
Flow Cytometry, IF, IHC, IHC-F, ICC, WB
$370
Cat # PB9921
100 μg/vial
Cat # PB9921
100 μg/vial
C1QBP Overview
Facts about Complement component 1 Q subcomponent-binding protein, mitochondrial.
Complement component 1 Q subcomponent-binding protein, mitochondrial (C1QBP)
Is believed to be a multifunctional and multicompartmental protein involved in inflammation and disease processes, ribosome biogenesis, protein synthesis in mitochondria, regulation of apoptosis, transcriptional regulation and pre-mRNA splicing. At the cell surface is supposed to act as an endothelial receptor for plasma proteins of the complement and kallikrein- kinin cascades.
Putative receptor for C1q; specifically binds to the globular"heads" of C1q thus inhibiting C1; may carry out the receptor function by means of a complex with C1qR/CD93. In complex with cytokeratin-1/KRT1 is a high affinity receptor for kininogen- 1/HMWK.
Gene Information
| Human | |
|---|---|
| Gene Name: | C1QBP |
| Uniprot: | Q07021 |
| Entrez: | 708 |
Family
| Belongs to: |
|---|
| MAM33 family |
Alternative Names
C1q globular domain-binding protein; C1QBP; complement component 1 Q subcomponent-binding protein, mitochondrial; complement component 1, q subcomponent binding protein; gC1qBP; GC1q-R protein; gC1qR; gC1Q-R; Glycoprotein gC1qBP; HABP1; HABP1p33; Hyaluronan-binding protein 1; Mitochondrial matrix protein p32; p32; SF2p32; splicing factor SF2-associated protein
Molecular Weight
Mass (kDA):
31.362 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 17p13.2 |
| Sequence: | 17; NC_000017.11 (5432777..5439155, complement) |
Tissue Specificity
Expressed on cell surface of peripheral blood cells (at protein level); Surface expression is reported for macrophages and monocyte-derived dendritic cells.
Subcellular Localizations
Mitochondrion matrix. Nucleus. Cell membrane; Peripheral membrane protein; Extracellular side. Secreted. Cytoplasm. Nucleus, nucleolus. Seems to be predominantly localized to mitochondria. Secreted by activated lymphocytes.
Diseases
- Inflammation
- Tissue Adhesions
- Neoplasms
- Malignant Neoplasms
- Headache
- Hepatitis
- Hepatitis C
- Virus Diseases
- Carcinoma
- Infective Disorder
- Hiv Infections
- Lupus Erythematosus, Systemic
- Neoplasm Metastasis
Interacting Proteins
- C1QA
- C1QB
- C1QC
- CDKN2A
- Cdkn2a
- F12
- FOXC1
- HRK
- KNG1
- MAVS
Pathways
- Phagocytosis
- Localization
- Complement Activation
- Cell Proliferation
- Pathogenesis
- Coagulation
- Chemotaxis
- Secretion
- Rna Interference
- Cell Adhesion
- Cell Activation
- Immune Response
- Fertilization
PTMs
- Phosphorylation
- Biotinylation
- Cleavage
- Glycosylation
Research Areas
- Stem Cell Markers
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/C1QBP
bosterbio.com/bosterbio-gene-info-cards/C1QBP
References
PMID: 8262387 by Honore B., et al. Cloning and expression of a cDNA covering the complete coding region of the P32 subunit of human pre-mRNA splicing factor SF2.
PMID: 8195709 by Ghebrehiwet B., et al. Isolation, cDNA cloning, and overexpression of a 33-kD cell surface glycoprotein that binds to the globular 'heads' of C1q.