This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
CACNA1H Antibodies
AND CACNA1H ELISA kits, CACNA1H Proteins
Many biological assays use antibodies to detect CACNA1H, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CACNA1H in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CACNA1H antibodies...
Designing a Western blot for CACNA1H? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the CACNA1H Western Blot GuideDesigning an IHC experiment for CACNA1H? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the CACNA1H IHC GuideCACNA1H Infographic by Boster Bio
All CACNA1H Products
Product
Figures
Specificity
Applications
Price
CACNA1H Overview
Facts about Voltage-dependent T-type calcium channel subunit alpha-1H.
Voltage-dependent T-type calcium channel subunit alpha-1H (CACNA1H)
Voltage-sensitive calcium channel which gives rise to T- type calcium currents. T-type calcium channels belong to the "low- voltage activated (LVA)" group.
A particularity of this type of channel is an opening at quite negative potentials, and a voltage- dependent inactivation (PubMed:9670923, PubMed:9930755, PubMed:27149520). T-type channels function pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle (Probable).
Gene Information
| Human | |
|---|---|
| Gene Name: | CACNA1H |
| Uniprot: | O95180 |
| Entrez: | 8912 |
Family
| Belongs to: |
|---|
| calcium channel alpha-1 subunit (TC 1.A.1.11) family |
Alternative Names
CACNA1HB; calcium channel, voltage-dependent, T type, alpha 1H subunit; calcium channel, voltage-dependent, T type, alpha 1Hb subunit; Cav3.2; ECA6; EIG6; FLJ90484; Low-voltage-activated calcium channel alpha1 3.2 subunit; low-voltage-activated calcium channel alpha13.2 subunit; voltage dependent t-type calcium channel alpha-1H subunit; voltage-dependent T-type calcium channel subunit alpha-1H; voltage-gated calcium channel alpha subunit Cav3.2; voltage-gated calcium channel alpha subunit CavT.2; Voltage-gated calcium channel subunit alpha Cav3.2
Molecular Weight
Mass (kDA):
259.163 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 16p13.3 |
| Sequence: | 16; NC_000016.10 (1153106..1221772) |
Tissue Specificity
In nonneuronal tissues, the highest expression levels are found in the kidney, liver, and heart. In the brain, most abundant in the amygdala, caudate nucleus, and putamen (PubMed:9670923, PubMed:9930755). In the heart, expressed in blood vessels. Isoform 1 and isoform 2 are expressed in testis, primarily in the germ cells, but not in other portions of the reproductive tract, such as ductus deferens. Isoform 2 is not detected in brain (PubMed:11751928). Expressed in the adrenal glomerulosa (at protein level) (PubMed:25907736, PubMed:27729216).
Subcellular Localizations
Cell membrane; Multi-pass membrane protein. Interaction with STAC increases expression at the cell membrane.
Diseases
- Epilepsy
- Absence Epilepsy
- Epilepsy, Generalized
- Caprine Arthritis-encephalitis
- Pain
- Malignant Neoplasms
- Autistic Disorder
- Diabetes Mellitus
- Diabetes Mellitus, Non-insulin-dependent
- Nervousness
- Neoplasms
- Channelopathies
Pathways
- Secretion
- Cell Proliferation
- Cortisol Secretion
- Transport
- Cell Cycle
- Hormone Secretion
- Localization
- Pathogenesis
- Muscle Cell Proliferation
- Dna Hypomethylation
- Brain Development
- Fertilization
- Muscle Contraction
PTMs
- Phosphorylation
- Biotinylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CACNA1H
bosterbio.com/bosterbio-gene-info-cards/CACNA1H
References
PMID: 9670923 by Cribbs L.L., et al. Cloning and characterization of alpha1H from human heart, a member of the T-type Ca2+ channel gene family.
PMID: 9930755 by Williams M.E., et al. Structure and functional characterization of a novel human low- voltage activated calcium channel.