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- Table of Contents
Facts about G2/mitotic-specific cyclin-B2.
Human | |
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Gene Name: | CCNB2 |
Uniprot: | O95067 |
Entrez: | 9133 |
Belongs to: |
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cyclin family |
CCNB2; Cyclin B2; G2/mitotic-specific cyclin-B2; HsT17299
Mass (kDA):
45.282 kDA
Human | |
---|---|
Location: | 15q22.2 |
Sequence: | 15; NC_000015.10 (59105146..59125045) |
When using the Anti-Cyclin B2/CCNB2 Marker, there are many uses. You can use it in many research applications, such as Circular visualization. However, there are many things you need to know before you can begin using this antibody. Below is a brief explanation of the application. It can also be used to determine if your sample is positive or negative.
The use of an Anti-Cyclin B2/CCNB2-Mater is a relatively new method for detecting cyclin B2 in gastrointestinal tissue. The cyclin B2 gene is expressed in many tissues of the gastrointestinal tract, including the colon, small intestine, stomach, and small bowel. The gene sequence is registered in the Genbank sequence database.
Cyclin B2 is the product of a transgenic mouse gene. Its promoter is designed to bind to NF-Y trimeric transcription factors. This protein is heteromeric, consisting of three subunits (NF-Ya, NF-Yb, and NF-Yc). The NF-Yb subunits increase cyclin B2 promoter activity during the mid-S phase and decrease its activity during the G2-M phase. The CCAAT-binding activity of cyclin B2 was confirmed by electrophoretic mobility shift assays. Furthermore, the NF-YA subunit is the limiting subunit in NF-Y complex.
The NF-Y gene is related to the proliferation of cells, including tumor cells. This cytoplasmic gene has a high expression level. It is also related to the expression of cyclin B2 and NF-YB. In colorectal cancer, the NF-Y subunits are expressed in the crypt base. This result was consistent with a previous study that found the NF-YB gene is expressed in the germinal center.
The anti-Cyclin B2/CCNB2 marker in Boster Bio has several applications. It is used to detect anti-cancer biomarkers in blood and tissue samples. The protein can also be used to detect anti-cancer drugs. One anti-Cyclin B2/CCNB2 marker in Boster Bio will help you identify the specific target for a certain cancer drug.
The CCNB2 marker was originally identified as a candidate biomarker for breast cancer. This gene is present on nearly half of all human breast tumors. In this study, we found a significant correlation between CCNB2 and ASPM protein levels. Hence, CCNB2 expression may be a biomarker for unfavorable outcomes in breast cancer. Further research is needed to determine if CCNB2 can help predict the outcome of breast cancer.
CCNB2 expression has been associated with different histological grades of breast cancer. This gene is also correlated with the IDH mutational status and 1p/19q codeletion status. It is not correlated with sex, although it may be useful for prognostication. Furthermore, CCNB2 expression is correlated with the stage of the disease in different types of cancer. In fact, CCNB2 expression is significantly associated with the prognosis of glioma, GBM, LGG, and PAAD.
Several studies have indicated that patients with high CCNB2 expression have a poor prognosis after LGG surgery. To further investigate if CCNB2 expression is associated with increased risk for LGG, pathway enrichment analysis was performed. Interestingly, CCNB2 was enriched in three pathways: adipogenesis, DNA repair, and the G2M-checkpoint. These three pathways are considered potential targets for cancer treatments.
The CCNB2 gene is overexpressed in breast tumors. This gene is an independent predictor of disease-specific survival in breast cancer patients. The predictive power of CCNB2 is 0.662. This gene expression is less than reliable than clinicopathological parameters, and has a decreasing tendency over time. Therefore, further research is needed to confirm the role of this marker in the diagnosis of breast cancer.
A Circular layout has numerous advantages. It is intuitive and elegant, and it enables the presentation of large amounts of data and complex relationships among various elements. This layout also allows for the display of multiple tracks of the same object or category, and it offers a highly organized method for presenting data. In addition to these advantages, it also looks great. This article will describe how to use a Circular layout to present your data.
The CCNB2 marker is a widely used biomarker for the cellular cytoskeleton in cells. Boster Bio produces high-affinity antibodies to this biomarker and enables scientists to perform ELISA, Western Blotting, and flow cytometry with confidence. The company's proprietary ELISA platform PicoKine(tm) is based on trade secrets developed by Steven Boster. This technology delivers highly sensitive, precise ELISA kits to the biomedical and diagnostic markets.
PMID: 11230166 by Wiemann S., et al. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.
PMID: 14702039 by Ota T., et al. Complete sequencing and characterization of 21,243 full-length human cDNAs.