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- Table of Contents
CCP110 Antibodies
AND CCP110 ELISA kits, CCP110 Proteins
Many biological assays use antibodies to detect CCP110, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CCP110 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CCP110 antibodies...
Designing a Western blot for CCP110? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the CCP110 Western Blot GuideDesigning an IHC experiment for CCP110? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the CCP110 IHC GuideCCP110 Infographic by Boster Bio
All CCP110 Products
Product
Figures
Specificity
Applications
Price
Human, Monkey, Mouse, Rat
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A05059-2
100 μg/vial
Cat # A05059-2
100 μg/vial
Human, Mouse, Rat
ELISA, IF, IHC, ICC, WB
$370
Cat # A05058-1
100 μg/vial
Cat # A05058-1
100 μg/vial
CCP110 Overview
Facts about Centriolar coiled-coil protein of 110 kDa.
Centriolar coiled-coil protein of 110 kDa (CCP110)
Necessary for centrosome duplication at different phases of procentriole formation. Acts as a key negative regulator of ciliogenesis in cooperation with CEP97 by capping the mother centriole thereby preventing cilia formation (PubMed:17719545 PubMed:17681131, PubMed:23486064).
Also involved in promoting ciliogenesis. May play a role in the assembly of the mother centriole subdistal appendages (SDA) thereby effecting the combination of recycling endosomes to basal bodies during cilia formation (By similarity).
Gene Information
| Human | |
|---|---|
| Gene Name: | CCP110 |
| Uniprot: | O43303 |
| Entrez: | 9738 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
centriolar coiled coil protein 110kDa; Cep110; CP110
Molecular Weight
Mass (kDA):
113.424 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 16p12.3 |
| Sequence: | 16; NC_000016.10 (19523879..19553408) |
Tissue Specificity
Highly expressed in testis. Detected at intermediate levels in spleen, thymus, prostate, small intestine, colon and peripheral blood leukocytes.
Subcellular Localizations
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, cilium basal body. Recruited early and then associates with the growing distal tips. Recruited to the mother centriole by KIF24. Removed from centrioles by TTBK2, leading to initiation of ciliogenesis and localizes only to the daughter centriole in ciliated cells. In cytotoxic T lymphocytes remains associated with the mother centriole during docking of the centrosome at the immunological synapse upon target contact.
Interacting Proteins
- CCNF
- CEP290
- CEP97
- CETN2
- KIF24
- NEURL4
PTMs
- Phosphoprotein
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CCP110
bosterbio.com/bosterbio-gene-info-cards/CCP110
References
PMID: 12361598 by Chen Z., et al. CP110, a cell cycle-dependent CDK substrate, regulates centrosome duplication in human cells.
PMID: 16760425 by Tsang W.Y., et al. CP110 cooperates with two calcium-binding proteins to regulate cytokinesis and genome stability.