CD109 antigen Antibodies

AND CD109 ELISA kits, CD109 antigen Proteins

Many biological assays use antibodies to detect CD109 antigen, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CD109 antigen in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CD109 antigen antibodies...

We validate the specificity of these antibodies to CD109 antigen by testing them on tissues known to express CD109 positively and negatively. Browse below to find the CD109 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Designing an IHC experiment for CD109 antigen? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.

Open the CD109 IHC Guide

CD109 Infographic by Boster Bio

All CD109 Products

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Price

Human CD109 ELISA Kit PicoKine®

Human

ELISA

$750
Cat # EK2147
96 wells/kit, with removable strips.

Anti-CD109 antigen CD109 Antibody

Immunohistochemical analysis of paraffin-embedded human-liver, antibody was diluted at 1:200

Human, Mouse

ELISA, IF, IHC

$380
Cat # A03248
100ul

CD109 Overview

Facts about CD109 antigen.

CD109 3D structure. Source: alphafold

CD109 antigen (CD109)

Modulates negatively TGFB1 signaling in keratinocytes. .

Gene Information

Human
Gene Name:	CD109
Uniprot:	Q6YHK3
Entrez:	135228

Family

Belongs to:

protease inhibitor I39 (alpha-2-macroglobulin) family

Alternative Names

150 kDa TGF-beta-1-binding protein; activated T-cell marker CD109; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 7; CD109 antigen (Gov platelet alloantigens); CD109 antigen; CD109 molecule; CD109; CPAMD7; CPAMD7r150; DKFZp762L1111; FLJ38569; FLJ41966; Gov platelet alloantigens; p180; Platelet-specific Gov antigen; RP11-525G3.1

Molecular Weight

Mass (kDA):
161.689 kDA

Genomic Context


Human

Location:	6q13
Sequence:	6; NC_000006.12 (73696085..73828317)

Tissue Specificity

Widely expressed with high level in uterus, aorta, heart, lung, trachea, placenta and in fetal heart, kidney, liver, spleen and lung. Expressed by CD34(+) acute myeloid leukemia cell lines, T-cell lines, activated T-lymphoblasts, endothelial cells and activated platelets. Isoform 4 is expressed in placenta. Isoform 1 is expressed in keratinocytes and placenta.

Subcellular Localizations

Cell membrane; Lipid-anchor, GPI-anchor.

Diseases

Malignant Neoplasms
Carcinoma
Neonatal Alloimmune Thrombocytopenia
Neoplasms
Malignant Squamous Cell Neoplasm
Alloimmunization
Malignant Paraganglionic Neoplasm
Purpura
Posttransfusion Purpura
Adenocarcinoma
Cell Transformation, Neoplastic
Refractoriness To Platelet Transfusion

Tissue Adhesions
Neoplasm Metastasis
Mammary Neoplasms
Melanoma
Thrombocytopenic Purpura
Von Willebrand Disease
Malignant Neoplasm Of Lung

Pathways

Localization
Cell Growth
Cell Proliferation
Pathogenesis
Cell Adhesion
Methylation
Glycosylation
Proteolysis
Dna Methylation
Menopause
Endocytosis
Leukocyte Differentiation

Oxidative Phosphorylation
Regeneration
Reverse Transcription
Keratinocyte Proliferation
Viral Replication
Monocyte Activation
Lymphocyte Activation

PTMs

Phosphorylation
Cleavage
Glycosylation

Methylation
Gpi Anchoring
Ubiquitination

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CD109

References

PMID: 11861284 by Lin M., et al. Cell surface antigen CD109 is a novel member of the alpha(2) macroglobulin/C3, C4, C5 family of thioester-containing proteins.

PMID: 14980714 by Solomon K.R., et al. CD109 represents a novel branch of the alpha2- macroglobulin/complement gene family.