CDC123 Antibodies

Cell division cycle protein 123 homolog (CDC123)

Required for S phase entry of the cell cycle. .

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Gene Information

Human
Gene Name:	CDC123
Uniprot:	O75794
Entrez:	8872

Family

Belongs to:
CDC123 family

Alternative Names

cell division cycle 123 homolog (S. cerevisiae); cell division cycle protein 123 homolog; chromosome 10 open reading frame 7; D123C10orf7; FLJ13863; HT-1080; Protein D123; PZ32

Molecular Weight

Mass (kDA):
39.135 kDA

Genomic Context

Human
Location:	10p14-p13
Sequence:	10; NC_000010.11 (12196188..12250589)

Tissue Specificity

Widely expressed. Expressed in spleen, thymus, prostate, testis, ovary, small intestine, colon and leukocytes with the highest expression in testis.

Subcellular Localizations

Cytoplasm.

Diseases

• Diabetes Mellitus
• Diabetes Mellitus, Non-insulin-dependent
• Insulin Resistance
• Insulin Sensitivity
• Obesity
• Adenocarcinoma
• Prediabetes Syndrome
• Varicosity
• Malignant Neoplasm Of Breast
• Heart Failure
• Renal Insufficiency
• Complications Of Diabetes Mellitus

• Lung Diseases
• Chronic Obstructive Airway Disease
• Lung Diseases, Obstructive
• Fibrosarcoma
• Malignant Neoplasms
• Neoplasms

Pathways

• Insulin Secretion
• Secretion
• Cell Cycle
• Cell Division
• Pathogenesis
• Protein Phosphorylation
• Translational Initiation
• Reverse Transcription

• G1 Phase
• Mitosis

PTMs

• Phosphorylation

Research Areas

• Cell Cycle and Replication

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CDC123

Boster Bio - Best Uses Of The CDC123 Marker

If you are looking for a CDC123 marker, you have come to the right spot. In this article, we will discuss the benefits of CDC123 and discuss Boster Bio's high-affinity primary antibodies. CDC123 is a unique antibody which binds to a single target proteins. It is ideal for a variety uses, including research and clinical practice.

CDC123 Marker

The CDC123 marker, a gene-controlled protein, is a part of the eukaryotic cell cycle. The cycle is controlled and controlled by cyclindependent kinases, cell division control proteins, and other sequences. One such protein is CDC123 (also known as D123), a 336 amino acid cytoplasmic protein. Its primary function involves destabilizing Chfr proteins which are crucial for the G–S transition. It also prevents cells from accumulating these proteins, thereby allowing cells not to undergo the G–S transition. This marker is found in the breast and is linked to luminal cancer.

Primary antibodies with high-affinity

CDC123 is a highly specific marker that has been shown to increase the affinity of primary antibodies to a given antigen. Competitive radioimmunoassays indicate that antibodies that bind strongly a particular antigen perform better than those that lack specificity. The CDC123 marker was used in several studies to determine antigen-antibody binding affinity. The antibody was extracted from rabbit serum using a library of PEG-linker (pTza) proteins. The PEG-1-pTza affinity column consisted of an input, flowthrough, washes, and a 10 ul column material. The elution fractions were then analyzed by SDS-PAGE and Coomassie staining.

The CDC123 marker can be used as an antibody to identify phosphorylated peptides. In these cases, antibodies can be converted to IgM. The CDC123 marker can also be used to identify monomers, dimers, and pentamers of antibodies. One monomer of an antibody might recognize multiple antigens, including the same peptide.

You can also identify the light chain complementarity determining area of monoclonal antibody. Monoclonal antibodies are composed of three chains: a heavy chain and a light one. The heavy and light chains are paired. They have an affinity for histidine-phosphorylated proteins. In the next section we will examine the role of this marker in monoclonal antibody production.

This marker allows researchers identify phosphorylated peptides via a signal transduction pathway. This means that antibodies that recognize phosphorylated peptides have high affinity to the CDC123 marker. These antibodies have a very specific nature. They can detect tumors and detect antibiotics. They are useful in determining the subject's reaction to an anticancer drug or biologic.

This specific antipHis residue is the focus of the CDC123 mAb. CDC123 has a high conservation rate from bacteria to people. Researchers can use this CDC123 marker in monoclonal antibodies that specifically recognize pHis, and other proteins phosphorylated on this site. This can help identify novel proteins that are involved in signal transduction pathways. CDC123 antibodies, which are highly specific, are ideal for detecting pHis.