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Cdk5rap3 Antibodies
AND Cdk5rap3 ELISA kits, Cdk5rap3 Proteins
Many biological assays use antibodies to detect Cdk5rap3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Cdk5rap3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Cdk5rap3 antibodies...
Designing an IHC experiment for Cdk5rap3? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the CDK5RAP3 IHC GuideCdk5rap3 Infographic by Boster Bio
All Cdk5rap3 Products
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Cdk5rap3 Overview
Facts about CDK5 regulatory subunit-associated protein 3.
CDK5 regulatory subunit-associated protein 3 (Cdk5rap3)
Probable tumor suppressor originally identified as a CDK5R1 interactor controlling cell proliferation. Negatively regulates NF-kappa-B-mediated gene transcription through the control of RELA phosphorylation.
Also regulates mitotic G2/M transition checkpoint and mitotic G2 DNA damage checkpoint. Through its interaction with CDKN2A/ARF and MDM2 may cause MDM2- dependent p53/TP53 ubiquitination, stabilization and activation in the nucleus, thereby promoting G1 cell cycle arrest and inhibition of cell proliferation.
Gene Information
| Rat | |
|---|---|
| Gene Name: | Cdk5rap3 |
| Uniprot: | Q9JLH7 |
| Entrez: | 80278 |
Family
| Belongs to: |
|---|
| CDK5RAP3 family |
Alternative Names
C53; CDK5 activator-binding protein C53; CDK5 regulatory subunit associated protein 3; FLJ13660; HSF-27; IC53CDK5 regulatory subunit-associated protein 3; ischemic heart CDK5 activator-binding protein C53; LXXLL/leucine-zipper-containing ARFbinding protein; LZAP; MST016; OK/SW-cl.114; Protein HSF-27
Molecular Weight
Mass (kDA):
57.045 kDA
Genomic Context
| Rat | |
|---|---|
| Location: | 10q31 |
| Sequence: | 10; |
Tissue Specificity
Expressed in vascular endothelium. Up- regulated in failing heart. Highly expressed in the ventricular section in subacute and chronic ischemic heart failure.
Diseases
- Neoplasms
- Malignant Neoplasms
- Carcinoma
- Cell Invasion
- Liver Carcinoma
- Neoplasm Invasiveness
- Carcinogenesis
- Malignant Tumor Of Colon
- Colorectal Cancer
- Hepatocarcinogenesis
- Colorectal Neoplasms
- Liver Neoplasms
Pathways
- Cell Cycle
- G1 Phase
- Cell Death
- Cell Proliferation
- Localization
- Transport
- Vasodilation
- Mitosis
- Dna Repair
- Conjugation
- Microtubule Nucleation
- Translation
- Cellular Localization
PTMs
- Phosphorylation
Research Areas
- Cell Cycle and Replication
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Cdk5rap3
bosterbio.com/bosterbio-gene-info-cards/Cdk5rap3
References
PMID: 10721722 by Ching Y.-P., et al. Cloning of three novel neuronal Cdk5 activator binding proteins.
PMID: 12054757 by Chen J., et al. A novel gene IC53 stimulates ECV304 cell proliferation and is upregulated in failing heart.