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- Table of Contents
Designing an IHC experiment for CEP78? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the CEP78 IHC GuideFacts about Centrosomal protein of 78 kDa.
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| Human | |
|---|---|
| Gene Name: | CEP78 |
| Uniprot: | Q5JTW2 |
| Entrez: | 84131 |

| Belongs to: |
|---|
| CEP78 family |

C9orf81; centrosomal protein 78kDa; centrosomal protein of 78 kDa; Cep78; chromosome 9 open reading frame 81; FLJ12643; FLJ52093; IP63; MGC135040
Mass (kDA):
76.396 kDA

| Human | |
|---|---|
| Location: | 9q21.2 |
| Sequence: | 9; NC_000009.12 (78236075..78279690) |
Widely expressed (PubMed:27588451, PubMed:27588452). Expressed in different retinal cell types with higher expression in cone compared to rod cells (at protein level) (PubMed:27588452).
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, cilium basal body. Mainly localizes at the centriolar wall, but also found in the pericentriolar material (PubMed:27246242). Expressed in photoreceptor inner segment (PubMed:27588452).



PMID: 27588451 by Nikopoulos K., et al. Mutations in CEP78 cause cone-rod dystrophy and hearing loss associated with primary-cilia defects.
PMID: 27588452 by Namburi P., et al. Bi-allelic truncating mutations in CEP78, encoding centrosomal protein 78, cause cone-rod degeneration with sensorineural hearing loss.