Cingulin Antibodies

AND CGN ELISA kits, Cingulin Proteins

Many biological assays use antibodies to detect Cingulin, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Cingulin in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Cingulin antibodies...

We validate the specificity of these antibodies to Cingulin by testing them on tissues known to express CGN positively and negatively. Browse below to find the CGN antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Designing a Western blot for Cingulin? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.

Open the CGN Western Blot Guide

Designing an IHC experiment for Cingulin? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.

Open the CGN IHC Guide

CGN Infographic by Boster Bio

All CGN Products

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Product

Figures

Specificity

Applications

Price

Anti-Cingulin CGN Antibody

Western blot analysis of extracts of various cell lines, using CGN antibody at 1:1000 dilution

Human

IHC, WB

$405
Cat # A02373
100ul

Anti-Cingulin/CGN Antibody

Human, Mouse, Rat

ELISA, IP, IHC, WB

$370
Cat # A02373-1
100 μl/vial

Cingulin (CGN) (NM_020770) Human Over-expression Lysate

Human

$960
Cat # LS057530
20 µg, 100 µg

CGN Overview

Facts about Cingulin.

CGN 3D structure. Source: alphafold

Cingulin (CGN)

Probably plays a role in the creation and regulation of the tight junction (TJ) paracellular permeability barrier. .

Gene Information

Human
Gene Name:	CGN
Uniprot:	Q9P2M7
Entrez:	57530

Family

Belongs to:

cingulin family

Alternative Names

cingulin; DKFZp779N1112; KIAA1319

Molecular Weight

Mass (kDA):
136.386 kDA

Genomic Context


Human

Location:	1q21.3
Sequence:	1; NC_000001.11 (151510858..151538692)

Tissue Specificity

Localized on the cytoplasmic face of tight junctions of polarized epithelia and some endothelia. Expressed in pancreas, kidney, liver and lung, but not in skeletal muscle, placenta, brain or heart.

Subcellular Localizations

Cell junction, tight junction. Localizes to the apical junction complex composed of tight and adherens junctions.

Diseases

Glomerulonephritis
Chronic Glomerulonephritis
Kidney Diseases
Kidney Failure
Kidney Failure, Chronic
Nephrotic Syndrome
Hypertensive Disease
Proteinuria Of Undiagnosed Cause
Nephritis
Diabetic Nephropathy
Neurotoxicity Syndromes
Tissue Adhesions
Lupus Erythematosus, Systemic

Inflammation
Crescentic Glomerulonephritis
Glomerulonephritis, Membranoproliferative
Malignant Neoplasms
Neoplasms
Glomerulosclerosis (disorder)
Diabetes Mellitus

Interacting Proteins

YWHAZ

Pathways

Cell Death
Excretion
Localization
Glomerular Filtration
Pathogenesis
Neuroprotection
Secretion
Translation
Cell Adhesion
Transport
Coagulation
Immune Response
Platelet Aggregation

Cell Proliferation
Fibrinolysis
Cell Cycle
Apoptotic Process
Axon Extension
Cell Differentiation
Humoral Immune Response

PTMs

Phosphorylation
Cleavage
Sulphation
Dephosphorylation
Oxidation
Ubiquitination
Nitration

Reduction
Demethylation
Deamination
Amidation
Glycosylation
Acetylation
Methylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CGN

References

PMID: 11042084 by Citi S., et al. Human and Xenopus cingulin share a modular organization of the coiled-coil rod domain: predictions for intra- and intermolecular assembly.

PMID: 12023291 by D'Atri F., et al. Evidence for a functional interaction between cingulin and ZO-1 in cultured cells.