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- Table of Contents
CHI3L1 Antibodies
AND CHI3L1 ELISA kits, CHI3L1 Proteins
Many biological assays use antibodies to detect CHI3L1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CHI3L1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CHI3L1 antibodies...
Designing a Western blot for CHI3L1? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the CHI3L1 Western Blot GuideCHI3L1 Infographic by Boster Bio
All CHI3L1 Products
Product
Figures
Specificity
Applications
Price
Human
ELISA
$499
Cat # EK0974
96 wells/kit, with removable strips.
Cat # EK0974
96 wells/kit, with removable strips.
Mouse
ELISA
$499
Cat # EK0975
96 wells/kit, with removable strips.
Cat # EK0975
96 wells/kit, with removable strips.
Human
ELISA
$499
Cat # FEK0974
96 wells/kit, with removable strips.
Cat # FEK0974
96 wells/kit, with removable strips.
Human
ELISA
$500
Cat # EZ0974
5 plates/kit
Cat # EZ0974
5 plates/kit
Mouse
ELISA
$499
Cat # FEK0975
96 wells/kit, with removable strips.
Cat # FEK0975
96 wells/kit, with removable strips.
Human, Mouse, Rat
ELISA, IF, ICC, WB
$370
Cat # A01283-3
100 μg/vial
Cat # A01283-3
100 μg/vial
Human
ELISA, Flow Cytometry, Functional Assay, Kinetics
$486
Cat # M01283
100 μg
Cat # M01283
100 μg
Human, Mouse, Rat
IF, IHC, WB
$380
Cat # A01283-2
100ul
Cat # A01283-2
100ul
Human
Cell Culture
$77
Cat # PROTP36222-4
5ug,20ug,100ug
Cat # PROTP36222-4
5ug,20ug,100ug
CHI3L1 Overview
Facts about Chitinase-3-like protein 1.
Chitinase-3-like protein 1 (CHI3L1)
Carbohydrate-binding lectin with a taste for chitin. Has no chitinase activity.
May play a role in tissue remodeling and in the capacity of cells to react to and cope with changes in their surroundings. Plays a role in T-helper cell type 2 (Th2) inflammatory response and IL-13-induced inflammation, regulating allergen sensitization, inflammatory cell apoptosis, dendritic cell accumulation and M2 macrophage differentiation.
Gene Information
| Human | |
|---|---|
| Gene Name: | CHI3L1 |
| Uniprot: | P36222 |
| Entrez: | 1116 |
Family
| Belongs to: |
|---|
| glycosyl hydrolase 18 family |
Alternative Names
AW208766; Brp39; CHI3L1; Chitinase 3 like 1; Chitinase 3-like 1; gp39; HCgp39; YKL-40
Molecular Weight
Mass (kDA):
42.625 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1q32.1 |
| Sequence: | 1; NC_000001.11 (203178931..203186704, complement) |
Tissue Specificity
Present in activated macrophages, articular chondrocytes, synovial cells as well as in liver. Very low or undetectable expression in non-inflammatory colon. Undetectable in muscle tissues, lung, pancreas, mononuclear cells, or fibroblasts.
Subcellular Localizations
Secreted, extracellular space. Cytoplasm. Cytoplasm, perinuclear region. Endoplasmic reticulum.
Diseases
- Inflammation
- Malignant Neoplasms
- Neoplasms
- Arthritis
- Rheumatoid Arthritis
- Degenerative Polyarthritis
- Fibrosis
- Asthma
- Glioblastoma
- Malignant Paraganglionic Neoplasm
- Diabetes Mellitus
- Brain Neoplasms
- Carcinoma
Interacting Proteins
- IL13RA2
- LGALS3
Pathways
- Tissue Remodeling
- Pathogenesis
- Secretion
- Angiogenesis
- Cell Proliferation
- Immune Response
- Localization
- Cell Migration
- Cell Cycle
- Cell Death
- Macrophage Activation
- Aging
PTMs
- Phosphorylation
- Methylation
- Carboxylation
- Glycosylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CHI3L1
bosterbio.com/bosterbio-gene-info-cards/CHI3L1
References
PMID: 8245017 by Hakala B.E., et al. Human cartilage gp-39, a major secretory product of articular chondrocytes and synovial cells, is a mammalian member of a chitinase protein family.
PMID: 9244440 by Rehli M., et al. Molecular characterization of the gene for human cartilage gp-39 (CHI3L1), a member of the chitinase protein family and marker for late stages of macrophage differentiation.
4 Publications of Boster CHI3L1 Antibodies & ELISA Kits
- PubMed ID: 10.1186/s13024-017-0226-4, YKL-40 in the brain and cerebrospinal fluid of neurodegenerative dementias
- PubMed ID: 10.1097/MD.0000000000014920, Serum YKL-40 predicts long-term outcome in patients undergoing primary percutane...
- PubMed ID: 10.1038/s41434-020-00202-0, Adenovirus vector-mediated YKL-40 shRNA attenuates eosinophil airway inflammatio...
- PubMed ID: 10.1016/j.ajg.2021.03.002, Comparison between galectin-3 and YKL-40 levels for the assessment of liver fibr...
*More publications can be found for each product on its corresponding product page