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- Table of Contents
CISH Antibodies
AND CISH ELISA kits, CISH Proteins
Many biological assays use antibodies to detect CISH, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CISH in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CISH antibodies...
Designing a Western blot for CISH? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the CISH Western Blot GuideCISH Infographic by Boster Bio
All CISH Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, Flow Cytometry, WB
$370
Cat # A05991-1
100 μg/vial
Cat # A05991-1
100 μg/vial
CISH Overview
Facts about Cytokine-inducible SH2-containing protein.
Cytokine-inducible SH2-containing protein (CISH)
SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. CIS is involved in the negative regulation of cytokines that signal through the JAK-STAT5 pathway like erythropoietin, prolactin and interleukin 3 (IL3) receptor.
Inhibits STAT5 trans-activation by curbing its tyrosine phosphorylation. May be a substrate- recognition element of a SCF-like ECS (Elongin BC-CUL2/5-SOCS- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity).
Gene Information
| Human | |
|---|---|
| Gene Name: | CISH |
| Uniprot: | Q9NSE2 |
| Entrez: | 1154 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
CIS-1; CIS-1cytokine-inducible SH2-containing protein; CIScytokine-inducible inhibitor of signaling type 1B; CISH; cytokine inducible SH2-containing protein; G18Protein G18; SOCS; Suppressor of cytokine signaling
Molecular Weight
Mass (kDA):
28.663 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 3p21.2 |
| Sequence: | 3; NC_000003.12 (50606454..50611774, complement) |
Tissue Specificity
Expressed in various epithelial tissues. Abundantly expressed in liver and kidney, and to a lesser extent in lung. The tissue distribution of isoforms 1 and 1B is distinct.
Diseases
- Malignant Neoplasms
- Neoplasms
- Malignant Neoplasm Of Breast
- Mammary Neoplasms
- Carcinoma
- Neoplasm Metastasis
- Adenocarcinoma
- Ductal Breast Carcinoma
- Invasive Breast Carcinoma
- Malignant Paraganglionic Neoplasm
- Malignant Squamous Cell Neoplasm
- Ductal Carcinoma
Interacting Proteins
- EGFR
- ERBB2
Pathways
- Pathogenesis
- Peroxidase Reaction
- Cell Growth
- Cell Proliferation
- Localization
- Interphase
- Cell Cycle
- Immune Response
- Proteolysis
- Regulation Of Gene Expression
- Reverse Transcription
- Hemostasis
- Cell Adhesion
PTMs
- Phosphorylation
- Methylation
Research Areas
- Signal Transduction
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CISH
bosterbio.com/bosterbio-gene-info-cards/CISH
References
PMID: 9465889 by Uchida K., et al. Molecular cloning of CISH, chromosome assignment to 3p21.3, and analysis of expression in fetal and adult tissues.
PMID: 10902923 by Jiang C., et al. Cloning and characterization of CIS 1b (cytokine inducible SH2- containing protein 1b), an alternative splicing form of CIS 1 gene.