Claudin-4 Antibodies

AND CLDN4 ELISA kits, Claudin-4 Proteins

Many biological assays use antibodies to detect Claudin-4, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Claudin-4 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Claudin-4 antibodies...

We validate the specificity of these antibodies to Claudin-4 by testing them on tissues known to express CLDN4 positively and negatively. Browse below to find the CLDN4 antibody that suites your experiment. We have 9 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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CLDN4 Infographic by Boster Bio

All CLDN4 Products

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Product

Figures

Specificity

Applications

Price

Anti-Claudin 4 Monoclonal Antibody

1 Citations 3 Q&As

Western blot analysis of Claudin 4 expression in MCF7 cell lysate

Human

IP, IHC, WB

$370
Cat # M03683
100 μl

Anti-CLAUDIN4 CLDN4 Antibody

Human

ELISA, IF, WB

$481
Cat # A03683
0.1 mg

Anti-Claudin-4 (P192) CLDN4 Antibody

Western blot (WB) analysis of Claudin-4 (P192) polyclonal antibody at 1:500 dilution
Lane1:A549 whole cell lysate(40ug)
Lane2:HCT116 whole cell lysate(40ug)
Lane3:DLD whole cell lysate(40ug)

Immunohistochemistry (IHC) analyzes of Claudin-4 (P192) pAb in paraffin-embedded human breast carcinoma tissue at 1:100

Immunoprecipitation of HCT116 cell lysate using Claudin-4 (P192) pAb (Sepharose Bead Conjugate) #BD0048(lane 2 and lane 3) and Nonspecific IgG Control (Sepharose Bead Conjugate) #BD0048 (lane 4 )

Human, Mouse, Rat

IP, IF, IHC, WB

$405
Cat # A03683-1
100ul

Anti-Claudin-4 (phospho-Y208) CLDN4 Antibody

Western blot (WB) analysis of Claudin-4 (phospho-Y208) polyclonal antibody at 1:500 dilution
Lane1:The Embryo tissue lysate of Mouse(40ug)
Lane2:The Uterus tissue lysate of Rat(40ug)
Lane3:Panc1 whole cell lysate(40ug)
Lane4:HCT116 whole cell lysate(40ug)

Human, Mouse, Rat

$482
Cat # A03683Y208
100ul

Anti-Phospho-Claudin-4 (Y208) CLDN4 Antibody

Immunohistochemical analysis of paraffin-embedded human tonsil

Human, Mouse, Rat

ELISA, IF, IHC

$380
Cat # A03683Y208-1
100ul

Claudin 4 (CLDN4) (NM_001305) Human Recombinant Protein

Coomassie blue staining of purified CLDN4 protein

$1249
Cat # PROTO14493
20 µg

Claudin 4 (CLDN4) (NM_001305) Human Over-expression Lysate

Human

$628
Cat # LS001364
20 µg, 100 µg

Anti-Claudin 4/CLDN4-Specific antibody

IHC analysis of Claudin 4/CLDN4-Specific using anti-Claudin 4/CLDN4-Specific antibody (A03683-2)

Human, Mouse, Rat

ELISA, IP, IF, IHC, WB

$370
Cat # A03683-2
100 μl/vial

Anti-Phospho-Claudin 4/CLDN4 (Y208) Antibody

Human, Mouse, Rat

IHC, WB

$370
Cat # P03683
100 μl/vial

CLDN4 Overview

Facts about Claudin-4.

CLDN4 3D structure. Source: alphafold

Claudin-4 (CLDN4)

Channel-forming tight junction protein which mediates paracellular chloride transport in the kidney. Plays a critical role in the paracellular reabsorption of filtered chloride in the kidney collecting ducts.

Claudins play a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. .

Gene Information

Human
Gene Name:	CLDN4
Uniprot:	O14493
Entrez:	1364

Family

Belongs to:

claudin family

Alternative Names

claudin 4; Claudin4; Claudin-4; CLDN4; Clostridium perfringens enterotoxin receptor 1; Clostridium perfringens enterotoxin receptor; CPE-R; CPE-RCPETR; CPE-receptor; CPETR1; hCPE-R; WBSCR8; WBSCR8CPERCPETR1claudin-4; Williams-Beuren syndrome chromosomal region 8 protein

Molecular Weight

Mass (kDA):
22.077 kDA

Genomic Context


Human

Location:	7q11.23
Sequence:	7; NC_000007.14 (73830863..73832693)

Subcellular Localizations

Cell junction, tight junction. Cell membrane; Multi-pass membrane protein. CLDN4 is required for tight junction localization in the kidney.

Diseases

Malignant Neoplasms
Neoplasms
Carcinoma
Adenocarcinoma
Neoplasm Metastasis
Tissue Adhesions
Cell Invasion
Ovarian Neoplasm
Malignant Paraganglionic Neoplasm
Malignant Neoplasm Of Ovary
Malignant Neoplasm Of Stomach
Cell Transformation, Neoplastic
Malignant Neoplasm Of Breast

Malignant Neoplasm Of Pancreas
Pancreatic Neoplasm
Stomach Neoplasms
Neoplasm Invasiveness
Mammary Neoplasms
Inflammation
Carcinogenesis

Pathways

Localization
Transport
Cell Adhesion
Pathogenesis
Methylation
Cell Growth
Dna Methylation
Cell Differentiation
Cell Proliferation
Cell-cell Adhesion
Cytolysis
Aging
Cell Death

Cell Migration
Dna Demethylation
Ion Transport
Demethylation
Secretion
Embryo Implantation
Cell Motility

PTMs

Phosphorylation
Methylation
Demethylation
Acetylation

Cleavage
Dephosphorylation
Glycosylation
Palmitoylation

Research Areas

Cancer
Extracellular Matrix

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CLDN4

References

PMID: 9334247 by Katahira J., et al. Clostridium perfringens enterotoxin utilizes two structurally related membrane proteins as functional receptors in vivo.

PMID: 16236711 by Tanaka M., et al. EphA2 phosphorylates the cytoplasmic tail of Claudin-4 and mediates paracellular permeability.