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- Table of Contents
Claudin-4 Antibodies
AND CLDN4 ELISA kits, Claudin-4 Proteins
Many biological assays use antibodies to detect Claudin-4, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Claudin-4 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Claudin-4 antibodies...
Designing a Western blot for Claudin-4? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the CLDN4 Western Blot GuideCLDN4 Infographic by Boster Bio
All CLDN4 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, IP, IF, IHC, WB
$370
Cat # A03683-2
100 μl/vial
Cat # A03683-2
100 μl/vial
Human, Mouse, Rat
ELISA
$480
Cat # EKC1121
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1121
1 kit, containing one 96-well plate and all necessary reagents
CLDN4 Overview
Facts about Claudin-4.
Claudin-4 (CLDN4)
Channel-forming tight junction protein which mediates paracellular chloride transport in the kidney. Plays a critical role in the paracellular reabsorption of filtered chloride in the kidney collecting ducts.
Claudins play a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. .
Gene Information
| Human | |
|---|---|
| Gene Name: | CLDN4 |
| Uniprot: | O14493 |
| Entrez: | 1364 |
Family
| Belongs to: |
|---|
| claudin family |
Alternative Names
claudin 4; Claudin4; Claudin-4; CLDN4; Clostridium perfringens enterotoxin receptor 1; Clostridium perfringens enterotoxin receptor; CPE-R; CPE-RCPETR; CPE-receptor; CPETR1; hCPE-R; WBSCR8; WBSCR8CPERCPETR1claudin-4; Williams-Beuren syndrome chromosomal region 8 protein
Molecular Weight
Mass (kDA):
22.077 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 7q11.23 |
| Sequence: | 7; NC_000007.14 (73830863..73832693) |
Subcellular Localizations
Cell junction, tight junction. Cell membrane; Multi-pass membrane protein. CLDN4 is required for tight junction localization in the kidney.
Diseases
- Malignant Neoplasms
- Neoplasms
- Carcinoma
- Adenocarcinoma
- Neoplasm Metastasis
- Tissue Adhesions
- Cell Invasion
- Ovarian Neoplasm
- Malignant Paraganglionic Neoplasm
- Malignant Neoplasm Of Ovary
- Malignant Neoplasm Of Stomach
- Cell Transformation, Neoplastic
- Malignant Neoplasm Of Breast
Pathways
- Localization
- Transport
- Cell Adhesion
- Pathogenesis
- Methylation
- Cell Growth
- Dna Methylation
- Cell Differentiation
- Cell Proliferation
- Cell-cell Adhesion
- Cytolysis
- Aging
- Cell Death
PTMs
- Phosphorylation
- Methylation
- Demethylation
- Acetylation
Research Areas
- Cancer
- Extracellular Matrix
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CLDN4
bosterbio.com/bosterbio-gene-info-cards/CLDN4
References
PMID: 9334247 by Katahira J., et al. Clostridium perfringens enterotoxin utilizes two structurally related membrane proteins as functional receptors in vivo.
PMID: 16236711 by Tanaka M., et al. EphA2 phosphorylates the cytoplasmic tail of Claudin-4 and mediates paracellular permeability.