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- Table of Contents
Chymase Antibodies
AND CMA1 ELISA kits, Chymase Proteins
Many biological assays use antibodies to detect Chymase, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Chymase in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Chymase antibodies...
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CMA1 Infographic by Boster Bio
All CMA1 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
IHC, WB
$370
Cat # PB9055
100 μg/vial
Cat # PB9055
100 μg/vial
CMA1 Overview
Facts about Chymase.
Chymase (CMA1)
Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion. .
Gene Information
| Human | |
|---|---|
| Gene Name: | CMA1 |
| Uniprot: | P23946 |
| Entrez: | 1215 |
Family
| Belongs to: |
|---|
| peptidase S1 family |
Alternative Names
Alpha-chymase; chymase 1 preproprotein transcript E; chymase 1 preproprotein transcript I; chymase 1, mast cell; Chymase; chymase, heart; chymase, mast cell; CMA1; CYH; CYM; EC 3.4.21; EC 3.4.21.39; Mast cell protease I; MCP3P; Mcpt5; MCT1; MGC119890; MGC119891
Molecular Weight
Mass (kDA):
27.325 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 14q12 |
| Sequence: | 14; NC_000014.9 (24505353..24508265, complement) |
Tissue Specificity
Mast cells in lung, heart, skin and placenta. Expressed in both normal skin and in urticaria pigmentosa lesions.
Subcellular Localizations
Secreted. Cytoplasmic granule. Mast cell granules.
Diseases
- Inflammation
- Asthma
- Eczema
- Dermatitis, Atopic
- Hypertrophy
- Hypertensive Disease
- Tuberculosis
- Fibrosis
- Dermatitis
- Cardiomyopathies
- Ulcer
- Tumor Angiogenesis
- Allergic Asthma
Pathways
- Pathogenesis
- Cell Proliferation
- Inflammatory Response
- Angiogenesis
- Cell Activation
- Vasodilation
- Endothelial Cell Activation
- Regulation Of Growth
- Immune Response
- Neutrophil Extravasation
- Complement Activation
- Senescence
- Flight
PTMs
- Cleavage
Research Areas
- Cell Biology
- Cellular Markers
- Immunology
- Innate Immunity
- Mast Cell Markers
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CMA1
bosterbio.com/bosterbio-gene-info-cards/CMA1
References
PMID: 2071582 by Caughey G.H., et al. Structure, chromosomal assignment, and deduced amino acid sequence of a human gene for mast cell chymase.
PMID: 1894611 by Urata H., et al. Cloning of the gene and cDNA for human heart chymase.