CKLF-like MARVEL transmembrane domain-containing protein 6 (CMTM6)

Master regulator of recycling and plasma membrane expression of PD-L1/CD274, a resistant inhibitory ligand critical for immune tolerance to self and antitumor immunity. Associates with both constitutive and IFNG-induced PD-L1/CD274 at recycling endosomes, where it protects PD-L1/CD274 from being targeted for lysosomal degradation, likely by preventing its STUB1-mediated ubiquitination.

May stabilize PD-L1/CD274 expression on antigen presenting cells and potentiates inhibitory signaling by PDCD1/CD279, its receptor on T-cells, finally triggering T-cell anergy. .