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- Table of Contents
CMTM6 Antibodies
AND CMTM6 ELISA kits, CMTM6 Proteins
Many biological assays use antibodies to detect CMTM6, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CMTM6 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CMTM6 antibodies...
Designing an IHC experiment for CMTM6? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the CMTM6 IHC GuideCMTM6 Infographic by Boster Bio
All CMTM6 Products
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Figures
Specificity
Applications
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CMTM6 Overview
Facts about CKLF-like MARVEL transmembrane domain-containing protein 6.
CKLF-like MARVEL transmembrane domain-containing protein 6 (CMTM6)
Master regulator of recycling and plasma membrane expression of PD-L1/CD274, a resistant inhibitory ligand critical for immune tolerance to self and antitumor immunity. Associates with both constitutive and IFNG-induced PD-L1/CD274 at recycling endosomes, where it protects PD-L1/CD274 from being targeted for lysosomal degradation, likely by preventing its STUB1-mediated ubiquitination.
May stabilize PD-L1/CD274 expression on antigen presenting cells and potentiates inhibitory signaling by PDCD1/CD279, its receptor on T-cells, finally triggering T-cell anergy. .
Gene Information
| Human | |
|---|---|
| Gene Name: | CMTM6 |
| Uniprot: | Q9NX76 |
| Entrez: | 54918 |
Family
| Belongs to: |
|---|
| chemokine-like factor family |
Alternative Names
chemokine-like factor super family 6; chemokine-like factor superfamily 6; Chemokine-like factor superfamily member 6; CKLF-like MARVEL transmembrane domain containing 6; CKLF-like MARVEL transmembrane domain-containing protein 6; CKLFSF6; FLJ20396; PRO2219
Molecular Weight
Mass (kDA):
20.419 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 3p22.3 |
| Sequence: | 3; NC_000003.12 (32481312..32502852, complement) |
Tissue Specificity
Expressed in the leukocytes, placenta and testis.
Subcellular Localizations
Cell membrane; Multi-pass membrane protein. Early endosome membrane; Multi-pass membrane protein. Recycling endosome membrane; Multi-pass membrane protein. Co-localizes with PD-L1/CD274 in the plasma membrane and in recycling endosomes.
Interacting Proteins
- CD274
Pathways
- Spermatogenesis
PTMs
- Acetylation
Research Areas
- Cytokine Research
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CMTM6
bosterbio.com/bosterbio-gene-info-cards/CMTM6
References
PMID: 12782130 by Han W., et al. Identification of eight genes encoding chemokine-like factor superfamily members 1-8 (CKLFSF1-8) by in silico cloning and experimental validation.
PMID: 28813417 by Burr M.L., et al. CMTM6 maintains the expression of PD-L1 and regulates anti-tumour immunity.