Cannabinoid receptor 2 Info At a glance, species: Human
Popular Antibodies & ELISA Kits
Cannabinoid receptor 2 (CNR2)
Heterotrimeric G protein-coupled receptor for endocannabinoid 2-arachidonoylglycerol mediating inhibition of adenylate cyclase. May function in inflammatory response, nociceptive transmission and bone homeostasis.
|G-protein coupled receptor 1 family|
Cannabinoid R2; cannabinoid receptor 2 (macrophage); CannabinoidR2; CB-2; CB2cannabinoid receptor 2; CB2R; CNR2; CX5; CX5testis-dominant CNR2 isoform CB2; hCB2
|Sequence:||1; NC_000001.11 (23870515..23913362, complement)|
Preferentially expressed in cells of the immune system with higher expression in B-cells and NK cells (at protein level). Expressed in skin in suprabasal layers and hair follicles (at protein level). Highly expressed in tonsil and to a lower extent in spleen, peripheral blood mononuclear cells, and thymus. PubMed:14657172 could not detect expression in normal brain. Expressed in brain by perivascular microglial cells and dorsal root ganglion sensory neurons (at protein level). Two isoforms are produced by alternative promoter usage and differ only in the 5' UTR: isoform CB2A is observed predominantly in testis with some expression in brain, while isoform CB2B is predominant in spleen and leukocytes.
Cell membrane; Multi-pass membrane protein. Cell projection, dendrite. Perikaryon. Localizes to apical dendrite of pyramidal neurons.
- Depressive Disorder
- Myocardial Reperfusion Injury
- Hyperalgesias, Mechanical
- Cell Death
- Immune Response
- Reverse Transcription
- Cell Activation
- Cell Proliferation
- Cell Cycle
- Bone Resorption
- Gastric Acid Secretion
- Prolactin Secretion
- Acid Secretion