CNR2 Infographic
Cannabinoid receptor 2 Info At a glance, species: Human
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Cannabinoid receptor 2 (CNR2)
Heterotrimeric G protein-coupled receptor for endocannabinoid 2-arachidonoylglycerol mediating inhibition of adenylate cyclase. May function in inflammatory response, nociceptive transmission and bone homeostasis.
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Gene Information
| Human | |
|---|---|
| Gene Name: | CNR2 |
| Uniprot: | P34972 |
| Entrez: | 1269 |
Family
| Belongs to: |
|---|
| G-protein coupled receptor 1 family |
Alternative Names
Cannabinoid R2; cannabinoid receptor 2 (macrophage); CannabinoidR2; CB-2; CB2cannabinoid receptor 2; CB2R; CNR2; CX5; CX5testis-dominant CNR2 isoform CB2; hCB2
Molecular Weight
Mass (kDA):
39.681 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1p36.11 |
| Sequence: | 1; NC_000001.11 (23870515..23913362, complement) |
Tissue Specificity
Preferentially expressed in cells of the immune system with higher expression in B-cells and NK cells (at protein level). Expressed in skin in suprabasal layers and hair follicles (at protein level). Highly expressed in tonsil and to a lower extent in spleen, peripheral blood mononuclear cells, and thymus. PubMed:14657172 could not detect expression in normal brain. Expressed in brain by perivascular microglial cells and dorsal root ganglion sensory neurons (at protein level). Two isoforms are produced by alternative promoter usage and differ only in the 5' UTR: isoform CB2A is observed predominantly in testis with some expression in brain, while isoform CB2B is predominant in spleen and leukocytes.
Subcellular Localizations
Cell membrane; Multi-pass membrane protein. Cell projection, dendrite. Perikaryon. Localizes to apical dendrite of pyramidal neurons.
Diseases
- Pain
- Inflammation
- Nervousness
- Hyperalgesia
- Pertussis
- Depressive Disorder
- Neoplasms
- Neuralgia
- Osteoporosis
- Infarction
- Ischemia
- Edema
Pathways
- Hypersensitivity
- Localization
- Transport
- Secretion
- Cell Death
- Pathogenesis
- Immune Response
- Reverse Transcription
- Cell Activation
- Cell Proliferation
- Cell Cycle
- Neuroprotection
- Bone Resorption
PTMs
- Phosphorylation
- Iodination
Research Areas
- GPCR
- Neuroscience
- Vision
bosterbio.com/bosterbio-gene-info-cards/CNR2
References
PMID: 7689702 by Munro S., et al. Molecular characterization of a peripheral receptor for cannabinoids.
PMID: 19496827 by Liu Q.-R., et al. Species differences in cannabinoid receptor 2 (CNR2 gene): identification of novel human and rodent CB2 isoforms, differential tissue expression and regulation by cannabinoid receptor ligands.
