Contactin-1 (CNTN1)

Contactins mediate cell surface interactions during nervous system development. Involved in the creation of paranodal axo-glial junctions in myelinated peripheral nerves and in the signaling between axons and myelinating glial cells via its association with CNTNAP1.

Participates in oligodendrocytes creation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation into the nucleus.