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- Table of Contents
Contactin-1 Antibodies
AND CNTN1 ELISA kits, Contactin-1 Proteins
Many biological assays use antibodies to detect Contactin-1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Contactin-1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Contactin-1 antibodies...
Designing a Western blot for Contactin-1? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the CNTN1 Western Blot GuideCNTN1 Infographic by Boster Bio
All CNTN1 Products
Product
Figures
Specificity
Applications
Price
Anti-Contactin 1/CNTN1 Antibody Picoband®
2 Citations
Human, Mouse, Rat
ELISA, IF, ICC, WB
$370
Cat # A04538-2
100 μg/vial
Cat # A04538-2
100 μg/vial
Human
ELISA
$499
Cat # EK1771
96 wells/kit, with removable strips.
Cat # EK1771
96 wells/kit, with removable strips.
Mouse
ELISA
$499
Cat # EK1772
96 wells/kit, with removable strips.
Cat # EK1772
96 wells/kit, with removable strips.
CNTN1 Overview
Facts about Contactin-1.
Contactin-1 (CNTN1)
Contactins mediate cell surface interactions during nervous system development. Involved in the creation of paranodal axo-glial junctions in myelinated peripheral nerves and in the signaling between axons and myelinating glial cells via its association with CNTNAP1.
Participates in oligodendrocytes creation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation into the nucleus.
Gene Information
| Human | |
|---|---|
| Gene Name: | CNTN1 |
| Uniprot: | Q12860 |
| Entrez: | 1272 |
Family
| Belongs to: |
|---|
| immunoglobulin superfamily |
Alternative Names
CNTN1; contactin 1; Contactin1; Contactin-1; F11; F3; F3cam; Glycoprotein gp135; GP135; Neural cell surface protein F3
Molecular Weight
Mass (kDA):
113.32 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 12q12 |
| Sequence: | 12; NC_000012.12 (40692429..41072415) |
Tissue Specificity
Strongly expressed in brain and in neuroblastoma and retinoblastoma cell lines. Lower levels of expression in lung, pancreas, kidney and skeletal muscle.
Subcellular Localizations
[Isoform 1]: Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side.; [Isoform 2]: Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side.
Diseases
- Tissue Adhesions
- Malignant Neoplasms
- Nervousness
- Neoplasms
- Cell Invasion
- Neoplasm Metastasis
- Metastatic Malignant Neoplasm To The Lymph Node
- Neoplasm Invasiveness
- Carcinoma
- Malignant Squamous Cell Neoplasm
- Lung Neoplasms
- Lymphatic Metastasis
- Myopathy
Interacting Proteins
- CNTNAP2
- PTPRZ1
Pathways
- Cell Adhesion
- Cell Proliferation
- Pathogenesis
- Lymphangiogenesis
- System Development
- Cell Cycle
- Localization
- Regeneration
- Nervous System Development
- Angiogenesis
- Rna Interference
- Secretion
- Cell Migration
PTMs
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CNTN1
bosterbio.com/bosterbio-gene-info-cards/CNTN1
References
PMID: 8164510 by Reid R.A., et al. Identification and characterization of the human cell adhesion molecule contactin.
PMID: 7959734 by Berglund E.O., et al. Molecular cloning and in situ localization of the human contactin gene (CNTN1) on chromosome 12q11-q12.
2 Publications of Boster Contactin-1 Antibodies & ELISA Kits
- PubMed ID: 10.1097/BRS.0b013e31825d4ebc, Increased Expression of Netrin-1 and Its Deleted in Colorectal Cancer Receptor i...
- PubMed ID: 10.1007/s11010-011-0882-6, Id1-induced inhibition of p53 facilitates endothelial cell migration and tube fo...
*More publications can be found for each product on its corresponding product page