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Coatomer subunit beta' Antibodies
AND COPB2 ELISA kits, Coatomer subunit beta' Proteins
Many biological assays use antibodies to detect Coatomer subunit beta', such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Coatomer subunit beta' in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Coatomer subunit beta' antibodies...
Designing an IHC experiment for Coatomer subunit beta'? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the COPB2 IHC GuideCOPB2 Infographic by Boster Bio
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COPB2 Overview
Facts about Coatomer subunit beta'.
Coatomer subunit beta' (COPB2)
The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non- clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.
In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity). .
Gene Information
| Human | |
|---|---|
| Gene Name: | COPB2 |
| Uniprot: | P35606 |
| Entrez: | 9276 |
Family
| Belongs to: |
|---|
| WD repeat COPB2 family |
Alternative Names
beta prime subunit; Beta'-coat protein; Beta'-COP; betaprime-COP; coatomer protein complex, subunit beta 2 (beta prime); coatomer subunit beta'; p102
Molecular Weight
Mass (kDA):
102.487 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 3q23 |
| Sequence: | 3; NC_000003.12 (139355595..139389680, complement) |
Subcellular Localizations
Cytoplasm, cytosol. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle, COPI-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it. Shows only a slight preference for the cis-Golgi apparatus, compared with the trans-Golgi.
Diseases
- Malignant Neoplasms
- Neoplasms
- Premature Menopause
- Pleural Neoplasms
- Glaucoma, Open-angle
- Scleroderma
- Infertility
- Neoplasm Invasiveness
- Malignant Neoplasm Of Lung
- Carcinoma
- Mucocutaneous Lymph Node Syndrome
- Yersinia Infections
Interacting Proteins
- NFKB1
Pathways
- Pathogenesis
- Cell Proliferation
- Localization
- Secretion
- Cell Cycle
- Cell Death
PTMs
- Acetylation
Research Areas
- Golgi Apparatus Markers
- Membrane Trafficking and Chaperones
- Neuroscience
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/COPB2
bosterbio.com/bosterbio-gene-info-cards/COPB2
References
PMID: 8335000 by Harrison-Lavoie K.J., et al. A 102 kDa subunit of a Golgi-associated particle has homology to beta subunits of trimeric G proteins.
PMID: 25129144 by Boztug K., et al. JAGN1 deficiency causes aberrant myeloid cell homeostasis and congenital neutropenia.