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- Table of Contents
Cytochrome P450 1A2 Antibodies
AND CYP1A2 ELISA kits, Cytochrome P450 1A2 Proteins
Many biological assays use antibodies to detect Cytochrome P450 1A2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Cytochrome P450 1A2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Cytochrome P450 1A2 antibodies...
Designing a Western blot for Cytochrome P450 1A2? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the CYP1A2 Western Blot GuideCYP1A2 Infographic by Boster Bio
All CYP1A2 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
IHC, WB
$370
Cat # PB9545
100 μg/vial
Cat # PB9545
100 μg/vial
Mouse, Rat
ELISA, Flow Cytometry, WB
$370
Cat # A00598
100 μg/vial
Cat # A00598
100 μg/vial
Human
Flow Cytometry, IF, IHC, WB
$523
Cat # M00598-1
100 µl
Cat # M00598-1
100 µl
Human
Flow Cytometry, IF, ICC, WB
$370
Cat # M00598
100 μl
Cat # M00598
100 μl
Human
$628
Cat # LS001544
20 µg, 100 µg
Cat # LS001544
20 µg, 100 µg
CYP1A2 Overview
Facts about Cytochrome P450 1A2.
Cytochrome P450 1A2 (CYP1A2)
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway.
It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Most active in catalyzing 2-hydroxylation.
Gene Information
| Human | |
|---|---|
| Gene Name: | CYP1A2 |
| Uniprot: | P05177 |
| Entrez: | 1544 |
Family
| Belongs to: |
|---|
| cytochrome P450 family |
Alternative Names
aryl hydrocarbon hydroxylase; CP12; CYPIA2; Cytochrome P(3)450; cytochrome P450 1A2; Cytochrome P450 4; cytochrome P450, family 1, subfamily A, polypeptide 2; cytochrome P450, subfamily I (aromatic compound-inducible), polypeptide 2; Cytochrome P450-P3; dioxin-inducible P3-450; EC 1.14.14.1; flavoprotein-linked monooxygenase; microsomal monooxygenase; P3-450; P450 form 4; P450(PA); xenobiotic monooxygenase
Molecular Weight
Mass (kDA):
58.407 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 15q24.1 |
| Sequence: | 15; NC_000015.10 (74748845..74756607) |
Tissue Specificity
Liver.
Subcellular Localizations
Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Diseases
- Malignant Neoplasms
- Neoplasms
- Carcinogenesis
- Liver Carcinoma
- Hepatotoxicity
- Malignant Neoplasm Of Breast
- Carcinoma
- Schizophrenia
- Depressive Disorder
- Liver Diseases
- Mammary Neoplasms
- Liver Neoplasms
Pathways
- Excretion
- Demethylation
- Conjugation
- Transport
- Localization
- Cell Proliferation
- Secretion
- Pathogenesis
- Reverse Transcription
- Cell Cycle
- Dna Repair
- Sulfation
- Methylation
PTMs
- Hydroxylation
- Demethylation
- Oxidation
- Acetylation
- Reduction
- Phosphorylation
- Methylation
- Nitration
- Cleavage
- Sulphation
Research Areas
- Cancer
- Lipid and Metabolism
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CYP1A2
bosterbio.com/bosterbio-gene-info-cards/CYP1A2
References
PMID: 3755823 by Jaiswal A.K., et al. Human P3(450): cDNA and complete amino acid sequence.
PMID: 3462722 by Quattrochi L.C., et al. Human cytochrome P-450 4 mRNA and gene: part of a multigene family that contains Alu sequences in its mRNA.
3 Publications of Boster Cytochrome P450 1A2 Antibodies & ELISA Kits
- PubMed ID: 10.1016/j.rvsc.2017.11.014, Effect of enrofloxacin and roxarsone on CYP450s in pig
- PubMed ID: 25217484, Fan X, Jiang Y, Wang Y, Tan H, Zeng H, Wang Y, Chen P, Qu A, Gonzalez Fj, Huang ...
- PubMed ID: 25319358, Jiang Y, Fan X, Wang Y, Chen P, Zeng H, Tan H, Gonzalez Fj, Huang M, Bi H. Toxic...
*More publications can be found for each product on its corresponding product page