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- Table of Contents
Cytochrome P450 1B1 Antibodies
AND CYP1B1 ELISA kits, Cytochrome P450 1B1 Proteins
Many biological assays use antibodies to detect Cytochrome P450 1B1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Cytochrome P450 1B1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Cytochrome P450 1B1 antibodies...
Designing a Western blot for Cytochrome P450 1B1? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the CYP1B1 Western Blot GuideCYP1B1 Infographic by Boster Bio
All CYP1B1 Products
Product
Figures
Specificity
Applications
Price
Anti-CYP1B1 Antibody Picoband®
1 Citations
Human, Mouse, Rat
Flow Cytometry, IHC, WB
$370
Cat # PB9546
100 μg/vial
Cat # PB9546
100 μg/vial
Human, Mouse, Rat
Flow Cytometry, IHC, WB
$370
Cat # M00515
100 μl/vial
Cat # M00515
100 μl/vial
CYP1B1 Overview
Facts about Cytochrome P450 1B1.
Cytochrome P450 1B1 (CYP1B1)
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway.
It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, retinoid and xenobiotics. Preferentially oxidizes 17beta- estradiol to the carcinogenic 4-hydroxy derivative, and many different procarcinogenic chemicals to their activated forms, such as polycyclic aromatic hydrocarbons.
Gene Information
| Human | |
|---|---|
| Gene Name: | CYP1B1 |
| Uniprot: | Q16678 |
| Entrez: | 1545 |
Family
| Belongs to: |
|---|
| cytochrome P450 family |
Alternative Names
aryl hydrocarbon hydroxylase; CP1B; CYPIB1; cytochrome P450 1B1; cytochrome P450, family 1, subfamily B, polypeptide 1; cytochrome P450, subfamily I (dioxin-inducible), polypeptide 1 (glaucoma 3; EC 1.14.14.1; flavoprotein-linked monooxygenase; GLC3A; microsomal monooxygenase; P4501B1; primary infantile); xenobiotic monooxygenase
Molecular Weight
Mass (kDA):
60.846 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 2p22.2 |
| Sequence: | 2; NC_000002.12 (38067603..38076181, complement) |
Tissue Specificity
Expressed in many tissues.
Subcellular Localizations
Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein. Mitochondrion. Located primarily in endoplasmic reticulum. Upon treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), CYP1B1 is also targeted to mitochondria.
Diseases
- Malignant Neoplasms
- Malignant Neoplasm Of Breast
- Neoplasms
- Mammary Neoplasms
- Glaucoma
- Carcinogenesis
- Hydrophthalmos
- Carcinoma
- Primary Congenital Glaucoma
- Glaucoma, Open-angle
- Adenocarcinoma
- Lung Neoplasms
- Intraocular Pressure Disorder
Pathways
- Pathogenesis
- Cell Cycle
- Cell Proliferation
- Localization
- Cell Growth
- Dna Repair
- Methylation
- Cell Death
- Transport
- Dna Methylation
- Menopause
- Conjugation
- Secretion
PTMs
- Hydroxylation
- Oxidation
- Methylation
- Phosphorylation
- Demethylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CYP1B1
bosterbio.com/bosterbio-gene-info-cards/CYP1B1
References
PMID: 8175734 by Sutter T.R., et al. Complete cDNA sequence of a human dioxin-inducible mRNA identifies a new gene subfamily of cytochrome P450 that maps to chromosome 2.
PMID: 8910454 by Tang Y.M., et al. Isolation and characterization of the human cytochrome P450 CYP1B1 gene.