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- Table of Contents
Alpha-crystallin B chain Antibodies
AND CRYAB ELISA kits, Alpha-crystallin B chain Proteins
Many biological assays use antibodies to detect Alpha-crystallin B chain, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Alpha-crystallin B chain in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Alpha-crystallin B chain antibodies...
Designing an IHC experiment for Alpha-crystallin B chain? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the CRYAB IHC GuideCRYAB Infographic by Boster Bio
All CRYAB Products
Product
Figures
Specificity
Applications
Price
Anti-Alpha B Crystallin/CRYAB Antibody Picoband®
1 Citations
Human, Monkey, Mouse, Rat
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A03496-2
100 μg/vial
Cat # A03496-2
100 μg/vial
Human, Rat
IP, IF, IHC, ICC, WB
$370
Cat # M03496
100 μl
Cat # M03496
100 μl
Human, Mouse, Rat
ELISA
$540
Cat # EKC2246
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2246
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC2245
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2245
1 kit, containing two 96-well plates and all necessary reagents
Human
$628
Cat # LS001410
20 µg, 100 µg
Cat # LS001410
20 µg, 100 µg
SDS-PAGE
$246
Cat # PROTP02511-2
Starting from 10ug
Cat # PROTP02511-2
Starting from 10ug
CRYAB Overview
Facts about Alpha-crystallin B chain.
Alpha-crystallin B chain (CRYAB)
May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a broad selection of stress conditions.
.
Gene Information
| Human | |
|---|---|
| Gene Name: | CRYAB |
| Uniprot: | P02511 |
| Entrez: | 1410 |
Family
| Belongs to: |
|---|
| small heat shock protein (HSP20) family |
Alternative Names
alpha B crystallin; alpha(B)-crystallin; AlphaB Crystallin; alpha-crystallin B chain; CRYA2; CRYA2alpha crystallin B chain; CRYAB; crystallin, alpha B; CTPP2; Heat shock protein beta-5; heat-shock 20 kD like-protein; HSPB5; Renal carcinoma antigen NY-REN-27; Rosenthal fiber component
Molecular Weight
Mass (kDA):
20.159 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 11q23.1 |
| Sequence: | 11; NC_000011.10 (111908564..111923740, complement) |
Tissue Specificity
Lens as well as other tissues (PubMed:838078, PubMed:2387586). Expressed in myocardial tissue (PubMed:28493373).
Subcellular Localizations
Cytoplasm. Nucleus. Translocates to the nucleus during heat shock and resides in sub-nuclear structures known as SC35 speckles or nuclear splicing speckles (PubMed:19464326). Localizes at the Z-bands and the intercalated disk in cardiomyocytes (PubMed:28493373).
Diseases
- Cardiomyopathies
- Myopathy
- Cataract
- Neoplasms
- Hypertrophy
- Malignant Neoplasms
- Heart Failure
- Neurodegenerative Disorders
- Sclerosis
- Multiple Sclerosis
- Cardiac Hypertrophy
- Carcinoma
Interacting Proteins
- CRYAA
- CRYBA1
- CRYGC
- CRYGS
- HSPB1
- HSPB2
- HSPB8
- Tmem109
Pathways
- Pathogenesis
- Cell Death
- Autophagy
- Immune Response
- Cell Growth
- Cell Adhesion
- Aging
- Angiogenesis
- Secretion
- Cell Differentiation
- Methylation
- Regeneration
- Protein Folding
PTMs
- Phosphorylation
- Ubiquitination
- Cleavage
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CRYAB
bosterbio.com/bosterbio-gene-info-cards/CRYAB
References
PMID: 838078 by Kramps J.A., et al. The primary structure of the B2 chain of human alpha-crystallin.
PMID: 2387586 by Dubin R.A., et al. Human alpha B-crystallin gene and preferential promoter function in lens.