L-dopachrome tautomerase Antibodies

AND DCT ELISA kits, L-dopachrome tautomerase Proteins

Many biological assays use antibodies to detect L-dopachrome tautomerase, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with L-dopachrome tautomerase in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop L-dopachrome tautomerase antibodies...

We validate the specificity of these antibodies to L-dopachrome tautomerase by testing them on tissues known to express DCT positively and negatively. Browse below to find the DCT antibody that suites your experiment. We have 5 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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DCT Infographic by Boster Bio

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Anti-TRP2 DCT Antibody

1 Q&As

Western blot analysis of lysates from K562 cells, using DCT Antibody

Immunofluorescence analysis of A549 cells, using DCT Antibody

Human, Mouse

ELISA, IF, IHC, WB

$380
Cat # A01830-1
100ul

Anti-L-dopachrome tautomerase DCT Antibody

Immunohistochemistry validation of DCT using Anti-L-dopachrome tautomerase DCT Antibody (A01830-2)

Human, Mouse

ELISA, IF, IHC, WB

$380
Cat # A01830-2
100ul

Human DCT Recombinant Protein

SDS-PAGE

$250
Cat # PROTP40126
Starting from 10ug

Anti-TRP2/DCT Antibody Picoband®

Western blot analysis of TRP2/DCT using anti-TRP2/DCT antibody (A01830-3)

Flow Cytometry analysis of MCF-7 cells using anti-TRP2/DCT antibody (A01830-3)

Human, Mouse, Rat

ELISA, Flow Cytometry, WB

$370
Cat # A01830-3
100 μg/vial

TRP2 (DCT) (NM_001922) Human Over-expression Lysate

Human

$628
Cat # LS001638
20 µg, 100 µg

DCT Overview

Facts about L-dopachrome tautomerase.

DCT 3D structure. Source: alphafold

L-dopachrome tautomerase (DCT)

Catalyzes the conversion of L-dopachrome into 5,6- dihydroxyindole-2-carboxylic acid (DHICA) (PubMed:8306979). Involved in regulating eumelanin and phaeomelanin levels.

Gene Information

Human
Gene Name:	DCT
Uniprot:	P40126
Entrez:	1638

Family

Belongs to:

tyrosinase family

Alternative Names

dopachrome delta-isomerase; dopachrome tautomerase (dopachrome delta-isomerase, tyrosine-related protein 2); DT; EC 5.3.3.12; L-dopachrome tautomerase; TRP2; TRP-2; Tyrosinase-related protein 2; TYRP2; TYRP2L-dopachrome Delta-isomerase

Molecular Weight

Mass (kDA):
59.145 kDA

Genomic Context


Human

Location:	13q32.1
Sequence:	13; NC_000013.11 (94436811..94549406, complement)

Subcellular Localizations

Melanosome membrane; Single-pass type I membrane protein. Melanosome. Proper trafficking to melanosome is regulated by SGSM2, ANKRD27, RAB9A, RAB32 and RAB38.

Diseases

Intraocular Pressure Disorder
Glaucoma
Corneal Diseases
Malignant Neoplasms
Neoplasms
Porphyria Cutanea Tarda
Melanoma
Hypertensive Disease
Glaucoma, Open-angle
Ocular Hypertension
Crest Syndrome
Mastitis, Bovine

Macule
Kidney Diseases
Disease Of Adrenal Medulla
Melanoma, Experimental
Carcinoma
Malignant Paraganglionic Neoplasm
Mastitis

Pathways

Transport
Pigmentation
Localization
Excretion
Secretion
Lactation
Pathogenesis
Melanocyte Differentiation
Cell Proliferation
Segmentation
Glomerular Filtration
Ion Transport
Aging

Cell Death
Cytokinesis
Reverse Transcription
Cellular Localization
Cell Differentiation
Regeneration
Diuresis

PTMs

Phosphorylation
Carboxylation
Cleavage
Glycosylation
Oxidation
Sumoylation
Deamination
Decarboxylation

Amidation
Ubiquitination
Iodination
Biotinylation
Nitration
Acetylation
Methylation
Deglycosylation

Research Areas

Lipid and Metabolism

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/DCT

References

PMID: 8148378 by Yokoyama K., et al. Molecular cloning and functional analysis of a cDNA coding for human DOPAchrome tautomerase/tyrosinase-related protein-2.

PMID: 8206391 by Cassady J.L., et al. Sequence of the human dopachrome tautomerase-encoding TRP-2 cDNA.