Diablo homolog, mitochondrial (DIABLO)

Promotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway. Acts by opposing the inhibitory activity of inhibitor of apoptosis proteins (IAP).

Inhibits the action of BIRC6/bruce by inhibiting its binding to caspases. Isoform 3 attenuates the stability and apoptosis- inhibiting action of XIAP/BIRC4 by boosting XIAP/BIRC4 ubiquitination and degradation during the ubiquitin-proteasome pathway.