- Table of Content
Inhibits the action of BIRC6/bruce by inhibiting its binding to caspases. Isoform 3 attenuates the stability and apoptosis- inhibiting action of XIAP/BIRC4 by boosting XIAP/BIRC4 ubiquitination and degradation during the ubiquitin-proteasome pathway.
|Sequence:||12; NC_000012.12 (122207662..122227456, complement)|
Ubiquitously expressed with highest expression in testis. Expression is also high in heart, liver, kidney, spleen, prostate and ovary. Low in brain, lung, thymus and peripheral blood leukocytes. Isoform 3 is ubiquitously expressed.
Mitochondrion. Released into the cytosol when cells undergo apoptosis.
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