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- Table of Contents
DUSP4 Antibodies
AND DUSP4 ELISA kits, DUSP4 Proteins
Many biological assays use antibodies to detect DUSP4, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with DUSP4 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop DUSP4 antibodies...
Designing a Western blot for DUSP4? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the DUSP4 Western Blot GuideDUSP4 Infographic by Boster Bio
All DUSP4 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA
$480
Cat # EKC1789
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1789
1 kit, containing one 96-well plate and all necessary reagents
DUSP4 Overview
Facts about Dual specificity protein phosphatase 4.
Dual specificity protein phosphatase 4 (DUSP4)
Regulates mitogenic signal transduction by dephosphorylating both Thr and Tyr residues on MAP kinases ERK1 and ERK2. .
Gene Information
| Human | |
|---|---|
| Gene Name: | DUSP4 |
| Uniprot: | Q13115 |
| Entrez: | 1846 |
Family
| Belongs to: |
|---|
| protein-tyrosine phosphatase family |
Alternative Names
dual specificity phosphatase 4; Dual specificity protein phosphatase hVH2; EC 3.1.3.16; EC 3.1.3.48; HVH2serine/threonine specific protein phosphatase; MAP kinase phosphatase 2; Mitogen-activated protein kinase phosphatase 2; MKP-2dual specificity protein phosphatase 4; MKP2VH1 homologous phosphatase 2; TYP; VH2
Molecular Weight
Mass (kDA):
42.953 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 8p12 |
| Sequence: | 8; NC_000008.11 (29333062..29350684, complement) |
Subcellular Localizations
Nucleus.
Diseases
- Malignant Neoplasms
- Neoplasms
- Carcinoma
- Malignant Neoplasm Of Breast
- Malignant Paraganglionic Neoplasm
- Mammary Neoplasms
- Leukemia, Myelocytic, Acute
- Tissue Adhesions
- Myeloid Leukemia
- Glioblastoma
- Leukemia
- Fibrosarcoma
- Pituitary Diseases
Interacting Proteins
- MAPK1
- MAPK9
Pathways
- Cell Proliferation
- Cell Cycle
- Cell Growth
- Localization
- Senescence
- Methylation
- Cell Death
- Mapk Cascade
- Pathogenesis
- Cell Adhesion
- Fibroblast Proliferation
- Cell Cycle Arrest
- Response To Oxidative Stress
PTMs
- Phosphorylation
- Dephosphorylation
- Methylation
Research Areas
- Cell Cycle and Replication
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/DUSP4
bosterbio.com/bosterbio-gene-info-cards/DUSP4
References
PMID: 7535768 by Guan K.-L., et al. Isolation and characterization of a novel dual specific phosphatase, HVH2, which selectively dephosphorylates the mitogen-activated protein kinase.
PMID: 8626452 by Chu Y., et al. The mitogen-activated protein kinase phosphatases PAC1, MKP-1, and MKP-2 have unique substrate specificities and reduced activity in vivo toward the ERK2 sevenmaker mutation.