DUSP4 Antibodies

AND DUSP4 ELISA kits, DUSP4 Proteins

Many biological assays use antibodies to detect DUSP4, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with DUSP4 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop DUSP4 antibodies...

We validate the specificity of these antibodies to DUSP4 by testing them on tissues known to express DUSP4 positively and negatively. Browse below to find the DUSP4 antibody that suites your experiment. We have 7 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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DUSP4 Infographic by Boster Bio

All DUSP4 Products

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Specificity

Applications

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Anti-MKP-2 DUSP4 Antibody

4 Q&As

Western Blot analysis of HEPG2-UV cells using MKP-2 Polyclonal Antibody diluted at 1:1000 cells nucleus extracted by Minute TM Cytoplasmic and Nuclear Fractionation kit

Western blot analysis of lysates from RAW264

Immunohistochemistry analysis of paraffin-embedded human brain tissue, using DUSP4 Antibody

Human, Monkey, Mouse, Rat

ELISA, IF, IHC, WB

$399
Cat # A03486
100μl

Anti-DUSP4 Antibody

1 Q&As

Western Blot analysis of HEPG2-UV cells using MKP-2 Polyclonal Antibody diluted at 1:1000

Human, Monkey, Mouse, Rat

ELISA, IF, IHC, ICC, WB

$335
Cat # A30480
100ul

DUSP4 Colorimetric Cell-Based ELISA

Western blot analysis of extracts from RAW264

Human, Mouse, Rat

ELISA

$480
Cat # EKC1789
1 kit, containing one 96-well plate and all necessary reagents

Anti-MKP-2 (Y108) DUSP4 Antibody

Immunohistochemistry (IHC) analyzes of MKP-2 (Y108) pAb in paraffin-embedded human breast carcinoma tissue at 1:50

Human, Mouse, Rat

IHC

$405
Cat # A03486Y108
100ul

DUSP4 (NM_001394) Human Recombinant Protein

Coomassie blue staining of purified DUSP4 protein

$1062
Cat # PROTQ13115
20 µg

Anti-DUSP4 Mouse Monoclonal Antibody [Clone ID: OTI7C11]

1 Citations

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY DUSP4 (Right lane) cDNA for 48 hrs and lysed

PSC intervention downregulates DUSP4 and upregulates the MAPK signaling pathway

Overexpression of DUSP4 affects osteoclast formation

Human, Mouse, Rat

$523
Cat # M30480
100 µl

DUSP4 (NM_001394) Human Over-expression Lysate

DUSP4 Human Over-expression Lysates NM_001394

Human

$628
Cat # LS001846
20 µg, 100 µg

DUSP4 Overview

Facts about Dual specificity protein phosphatase 4.

DUSP4 3D structure. Source: alphafold

Dual specificity protein phosphatase 4 (DUSP4)

Regulates mitogenic signal transduction by dephosphorylating both Thr and Tyr residues on MAP kinases ERK1 and ERK2. .

Gene Information

Human
Gene Name:	DUSP4
Uniprot:	Q13115
Entrez:	1846

Family

Belongs to:

protein-tyrosine phosphatase family

Alternative Names

dual specificity phosphatase 4; Dual specificity protein phosphatase hVH2; EC 3.1.3.16; EC 3.1.3.48; HVH2serine/threonine specific protein phosphatase; MAP kinase phosphatase 2; Mitogen-activated protein kinase phosphatase 2; MKP-2dual specificity protein phosphatase 4; MKP2VH1 homologous phosphatase 2; TYP; VH2

Molecular Weight

Mass (kDA):
42.953 kDA

Genomic Context


Human

Location:	8p12
Sequence:	8; NC_000008.11 (29333062..29350684, complement)

Subcellular Localizations

Nucleus.

Diseases

Malignant Neoplasms
Neoplasms
Carcinoma
Malignant Neoplasm Of Breast
Malignant Paraganglionic Neoplasm
Mammary Neoplasms
Leukemia, Myelocytic, Acute
Tissue Adhesions
Myeloid Leukemia
Glioblastoma
Leukemia
Fibrosarcoma
Pituitary Diseases

Liver Carcinoma
Malignant Neoplasm Of Lung
Hypokinesia
Colorectal Cancer
Cell Invasion
Rectal Carcinoma
Systemic Infection

Interacting Proteins

MAPK1
MAPK9

Pathways

Cell Proliferation
Cell Cycle
Cell Growth
Localization
Senescence
Methylation
Cell Death
Mapk Cascade
Pathogenesis
Cell Adhesion
Fibroblast Proliferation
Cell Cycle Arrest
Response To Oxidative Stress

Gastrulation
Cell Activation
Cellular Senescence
Aging
Gluconeogenesis
Hypersensitivity
Hepatocyte Proliferation

PTMs

Phosphorylation
Dephosphorylation
Methylation

Demethylation
Reduction
Cleavage

Ubiquitination

Research Areas

Cell Cycle and Replication

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/DUSP4

References

PMID: 7535768 by Guan K.-L., et al. Isolation and characterization of a novel dual specific phosphatase, HVH2, which selectively dephosphorylates the mitogen-activated protein kinase.

PMID: 8626452 by Chu Y., et al. The mitogen-activated protein kinase phosphatases PAC1, MKP-1, and MKP-2 have unique substrate specificities and reduced activity in vivo toward the ERK2 sevenmaker mutation.