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- Table of Contents
DYRK1A Antibodies
AND DYRK1A ELISA kits, DYRK1A Proteins
Many biological assays use antibodies to detect DYRK1A, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with DYRK1A in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop DYRK1A antibodies...
Designing an IHC experiment for DYRK1A? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the DYRK1A IHC GuideDYRK1A Infographic by Boster Bio
All DYRK1A Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA
$480
Cat # EKC1804
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1804
1 kit, containing one 96-well plate and all necessary reagents
DYRK1A Overview
Facts about Dual specificity tyrosine-phosphorylation-regulated kinase 1A.
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A)
Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities. May play a role in a signaling pathway regulating nuclear functions of cell regeneration.
Modulates alternative splicing by phosphorylating the splice factor SRSF6 (By similarity). Has pro-survival function and negatively regulates the apoptotic process.
Gene Information
| Human | |
|---|---|
| Gene Name: | DYRK1A |
| Uniprot: | Q13627 |
| Entrez: | 1859 |
Family
| Belongs to: |
|---|
| protein kinase superfamily |
Alternative Names
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A; DYRK1; DYRK1A; MNBEC 2.7.110EC 2.7.12; MNBH
Molecular Weight
Mass (kDA):
85.584 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 21q22.13 |
| Sequence: | 21; NC_000021.9 (37365573..37526358) |
Tissue Specificity
Ubiquitous. Highest levels in skeletal muscle, testis, fetal lung and fetal kidney.
Subcellular Localizations
Nucleus. Nucleus speckle.
Diseases
- Down Syndrome
- Trisomy
- Alzheimer's Disease
- Malignant Neoplasms
- Neoplasms
- Neurofibrillary Tangles
- Neurodegenerative Disorders
- Nerve Degeneration
- Nervousness
- Dementia
- Partial Trisomy
- Microcephaly
Interacting Proteins
- DCAF7
- LZTS2
- RB1
- RBL1
- TROAP
- YWHAB
Pathways
- Brain Development
- Neurogenesis
- Localization
- Pathogenesis
- Cell Cycle
- Cell Death
- Cell Proliferation
- Hyperphosphorylation
- Rna Interference
- Aging
- Translation
- Mitosis
- Senescence
PTMs
- Phosphorylation
- Dephosphorylation
- Cleavage
Research Areas
- Protein Kinase
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/DYRK1A
bosterbio.com/bosterbio-gene-info-cards/DYRK1A
References
PMID: 8975710 by Song W.J., et al. Isolation of human and murine homologues of the Drosophila minibrain gene: human homologue maps to 21q22.2 in the Down syndrome 'critical region'.
PMID: 8872470 by Guimera J., et al. A human homologue of Drosophila minibrain (MNB) is expressed in the neuronal regions affected in Down syndrome and maps to the critical region.