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- Table of Contents
Acyl-CoA-binding protein Antibodies
AND DBI ELISA kits, Acyl-CoA-binding protein Proteins
Many biological assays use antibodies to detect Acyl-CoA-binding protein, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Acyl-CoA-binding protein in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Acyl-CoA-binding protein antibodies...
Designing a Western blot for Acyl-CoA-binding protein? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the DBI Western Blot GuideDesigning an IHC experiment for Acyl-CoA-binding protein? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the DBI IHC GuideDBI Infographic by Boster Bio
All DBI Products
Product
Figures
Specificity
Applications
Price
Human
Flow Cytometry, IF, IHC, IHC-F, ICC, WB
$370
Cat # A01267
100 μg/vial
Cat # A01267
100 μg/vial
Human
$628
Cat # LS001622
20 µg, 100 µg
Cat # LS001622
20 µg, 100 µg
DBI Overview
Facts about Acyl-CoA-binding protein.
Acyl-CoA-binding protein (DBI)
Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters. It is also able to displace diazepam from the benzodiazepine (BZD) recognition site located on the GABA type A receptor.
It is thus possible that this protein also acts as a neuropeptide to modulate the activity of the GABA receptor. .
Gene Information
| Human | |
|---|---|
| Gene Name: | DBI |
| Uniprot: | P07108 |
| Entrez: | 1622 |
Family
| Belongs to: |
|---|
| ACBP family |
Alternative Names
acyl-Coenzyme A binding domain containing 1; acyl-Coenzyme A bindingprotein); CCK-RP; cholecystokinin-releasing peptide, trypsin-sensitive; diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein); Diazepam-binding inhibitor; endozepine; EP; GABA receptor modulator; MGC70414
Molecular Weight
Mass (kDA):
10.044 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 2q14.2 |
| Sequence: | 2; NC_000002.12 (119366977..119372560) |
Tissue Specificity
Isoform 1 is ubiquitous, with a moderate expression level. Isoform 2 is ubiquitous with high level in liver and adipose tissue. Isoform 3 is ubiquitous with strong expression in adipose tissue and heart.
Subcellular Localizations
Endoplasmic reticulum. Golgi apparatus. Golgi localization is dependent on ligand binding (PubMed:17953517).
Diseases
- Diabetes Mellitus
- Anxiety Disorders
- Nervousness
- Neoplasms
- Substance Withdrawal Syndrome
- Ischemia
- Pituitary Diseases
- Depressive Disorder
- Malignant Neoplasms
- Brain Injuries
- Stress, Psychological
- Alzheimer's Disease
Pathways
- Secretion
- Transport
- Localization
- Insulin Secretion
- Cell Proliferation
- Pathogenesis
- Cholesterol Transport
- Cell Growth
- Excretion
- Aging
- Cell Death
- Transposition
- Glial Cell Proliferation
PTMs
- Cleavage
- Phosphorylation
- Phosphorothioation
- Reduction
Research Areas
- Cancer
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/DBI
bosterbio.com/bosterbio-gene-info-cards/DBI
References
PMID: 3020548 by Gray P.W., et al. Cloning and expression of cDNA for human diazepam binding inhibitor, a natural ligand of an allosteric regulatory site of the gamma- aminobutyric acid type A receptor.
PMID: 2881742 by Webb N.R., et al. Bovine and human cDNA sequences encoding a putative benzodiazepine receptor ligand.