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- Table of Contents
DNMT3A Antibodies
AND DNMT3A ELISA kits, DNMT3A Proteins
Many biological assays use antibodies to detect DNMT3A, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with DNMT3A in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop DNMT3A antibodies...
Designing a Western blot for DNMT3A? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the DNMT3A Western Blot GuideDesigning an IHC experiment for DNMT3A? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the DNMT3A IHC GuideDNMT3A Infographic by Boster Bio
All DNMT3A Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, Flow Cytometry, IP, IF, IHC, ICC, WB
$370
Cat # A00136-2
100 μl/vial
Cat # A00136-2
100 μl/vial
Anti-Dnmt3a Rabbit Monoclonal Antibody
2 Citations
Human, Mouse, Rat
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # M00136
100 μl
Cat # M00136
100 μl
DNMT3A Overview
Facts about DNA (cytosine-5)-methyltransferase 3A.
DNA (cytosine-5)-methyltransferase 3A (DNMT3A)
Required for genome-wide de novo methylation and is vital for the organization of DNA methylation patterns during development. It modifies DNA in a non-processive fashion and also methylates non-CpG websites.
May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting.
Gene Information
| Human | |
|---|---|
| Gene Name: | DNMT3A |
| Uniprot: | Q9Y6K1 |
| Entrez: | 1788 |
Family
| Belongs to: |
|---|
| class I-like SAM-binding methyltransferase superfamily |
Alternative Names
64B1446 clone; DNA (cytosine-5-)-methyltransferase 3 alpha; DNA (cytosine-5)-methyltransferase 3A; DNA cytosine methyltransferase 3A2; DNA Methyltransferase 3 Alpha; DNA methyltransferase HsaIIIA; DNA MTase HsaIIIA; DNMT3A; DNMT3A2; EC 2.1.1.37; M.HsaIIIA; TBRS
Molecular Weight
Mass (kDA):
101.858 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 2p23.3 |
| Sequence: | 2; NC_000002.12 (25227874..25342590, complement) |
Tissue Specificity
Highly expressed in fetal tissues, skeletal muscle, heart, peripheral blood mononuclear cells, kidney, and at lower levels in placenta, brain, liver, colon, spleen, small intestine and lung.
Subcellular Localizations
Nucleus. Cytoplasm. Accumulates in the major satellite repeats at pericentric heterochromatin.
Diseases
- Malignant Neoplasms
- Neoplasms
- Leukemia
- Myeloid Leukemia
- Leukemia, Myelocytic, Acute
- Carcinoma
- Cell Transformation, Neoplastic
- Carcinogenesis
- Dysmyelopoietic Syndromes
- Malignant Paraganglionic Neoplasm
- Immunologic Deficiency Syndromes
- Malignant Neoplasm Of Breast
Interacting Proteins
- CREM
- EED
- EZH2
- H3F3A
- PRMT5
- SETDB1
- SP100
- TCL1A
- UHRF1
Pathways
- Methylation
- Dna Methylation
- Demethylation
- Pathogenesis
- Gene Silencing
- Cell Cycle
- Dna Hypomethylation
- Localization
- Dna Hypermethylation
- Cell Differentiation
- Aging
- Embryo Development
- Regulation Of Gene Expression
PTMs
- Methylation
- Demethylation
- Acetylation
- Deacetylation
- Cleavage
- Phosphorylation
Research Areas
- Adaptive Immunity
- Cancer
- Chromatin Research
- Epigenetics
- Innate Immunity
- Tumor Suppressors
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/DNMT3A
bosterbio.com/bosterbio-gene-info-cards/DNMT3A
References
PMID: 10433969 by Xie S., et al. Cloning, expression and chromosome locations of the human DNMT3 gene family.
PMID: 12138111 by Chen T., et al. A novel Dnmt3a isoform produced from an alternative promoter localizes to euchromatin and its expression correlates with active de novo methylation.