EDEM2 Antibodies

AND EDEM2 ELISA kits, EDEM2 Proteins

Many biological assays use antibodies to detect EDEM2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with EDEM2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop EDEM2 antibodies...

We validate the specificity of these antibodies to EDEM2 by testing them on tissues known to express EDEM2 positively and negatively. Browse below to find the EDEM2 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Designing an IHC experiment for EDEM2? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.

Open the EDEM2 IHC Guide

EDEM2 Infographic by Boster Bio

All EDEM2 Products

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Product

Figures

Specificity

Applications

Price

C20orf31 (EDEM2) (NM_018217) Human Over-expression Lysate

C20orf31 (EDEM2) Human Over-expression Lysates NM_001145025

Human

$628
Cat # LS055741
20 µg, 100 µg

Anti-EDEM2 Antibody

Immunohistochemical analysis of paraffin-embedded human tonsil

Human, Mouse

ELISA, IF, IHC

$380
Cat # A08174
100ul

EDEM2 Overview

Facts about ER degradation-enhancing alpha-mannosidase-like protein 2.

EDEM2 3D structure. Source: alphafold

ER degradation-enhancing alpha-mannosidase-like protein 2 (EDEM2)

Involved from the endoplasmic reticulum-associated degradation (ERAD) pathway that targets misfolded glycoproteins for degradation in an N-glycan-dependent manner (PubMed:15537790, PubMed:25092655). May initiate ERAD by encouraging the first mannose trimming step of ERAD substrates, from Man9GlcNAc2 to Man8GlcNAc2 (PubMed:25092655).

Seems to recognize and bind to exposed hydrophobic regions in target proteins (By similarity). .

Gene Information

Human
Gene Name:	EDEM2
Uniprot:	Q9BV94
Entrez:	55741

Family

Belongs to:

glycosyl hydrolase 47 family

Alternative Names

bA4204.1; C20orf31; C20orf49; chromosome 20 open reading frame 31; ER degradation enhancer, mannosidase alpha-like 2; ER degradation-enhancing alpha-mannosidase-like 2; ER degradation-enhancing-mannosidase-like protein 2; FLJ10783

Molecular Weight

Mass (kDA):
64.753 kDA

Genomic Context


Human

Location:	20q11.22
Sequence:	20; NC_000020.11 (35115364..35147336, complement)

Tissue Specificity

Expressed ubiquitously in all tissues tested with slightly higher levels detected in small intestine and peripheral blood leukocytes and weakest levels in brain and skeletal muscle.

Subcellular Localizations

Endoplasmic reticulum lumen.

Diseases

Thromboembolism
Atherosclerosis
Physiological Stress
Hepatitis B
Constipation
Coronary Artery Disease
Endoplasmic Reticulum Stress
Mucopolysaccharidoses
Usual Interstitial Pneumonitis
Fibrosis
Lysosomal Storage Diseases
Mucopolysaccharidosis I
Venous Thromboembolism

Cerebral Ischemia
Infective Disorder
Ischemia
Hepatitis
Thrombophilia
Pulmonary Fibrosis
Pneumonia

Pathways

Pathogenesis
Transport
Cell Death
Protein Folding
Proteolysis
Hemostasis
Protein Processing

Secretion

PTMs

Phosphorylation

Research Areas

Lipid and Metabolism

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/EDEM2

References

PMID: 15537790 by Mast S.W., et al. Human EDEM2, a novel homolog of family 47 glycosidases, is involved in ER-associated degradation of glycoproteins.

PMID: 25092655 by Ninagawa S., et al. EDEM2 initiates mammalian glycoprotein ERAD by catalyzing the first mannose trimming step.