ER degradation-enhancing alpha-mannosidase-like protein 2 (EDEM2)

Involved from the endoplasmic reticulum-associated degradation (ERAD) pathway that targets misfolded glycoproteins for degradation in an N-glycan-dependent manner (PubMed:15537790, PubMed:25092655). May initiate ERAD by encouraging the first mannose trimming step of ERAD substrates, from Man9GlcNAc2 to Man8GlcNAc2 (PubMed:25092655).

Seems to recognize and bind to exposed hydrophobic regions in target proteins (By similarity). .