Ephrin-A5 Antibodies

Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases that are crucial for migration, repulsion and adhesion during adrenal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, resulting in contact-dependent bidirectional signaling into neighboring cells.

The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Induces compartmentalized signaling inside a caveolae-like membrane microdomain when bound to the extracellular domain of its cognate receptor.