Ephrin-B1 (EFNB1)

Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases that are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development (PubMed:8070404, PubMed:7973638). Binding to Eph receptors residing on adjacent cells leads to contact- dependent bidirectional signaling into neighboring cells (PubMed:8070404, PubMed:7973638).

Shows high affinity for the receptor tyrosine kinase EPHB1/ELK (PubMed:8070404, PubMed:7973638). Can also bind EPHB2 and EPHB3 (PubMed:8070404).