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- Table of Contents
ELP3 Antibodies
AND ELP3 ELISA kits, ELP3 Proteins
Many biological assays use antibodies to detect ELP3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ELP3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ELP3 antibodies...
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ELP3 Infographic by Boster Bio
All ELP3 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
IP, IF, ICC, WB
$370
Cat # M02833
100 μl
Cat # M02833
100 μl
Human, Mouse, Rat
WB
$370
Cat # M02833-1
100 μg/vial
Cat # M02833-1
100 μg/vial
ELP3 Overview
Facts about Elongator complex protein 3.
Elongator complex protein 3 (ELP3)
Catalytic histone acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and likely H4.
May also have a methyltransferase activity. Involved in cell migration.
Gene Information
| Human | |
|---|---|
| Gene Name: | ELP3 |
| Uniprot: | Q9H9T3 |
| Entrez: | 55140 |
Family
| Belongs to: |
|---|
| ELP3 family |
Alternative Names
EC 2.3.1.48; elongation protein 3 homolog (S. cerevisiae); elongator complex protein 3; hELP3; KAT9FLJ10422
Molecular Weight
Mass (kDA):
62.259 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 8p21.1 |
| Sequence: | 8; NC_000008.11 (28090232..28191153) |
Tissue Specificity
Expressed in the cerebellum and spinal motor neurons.
Subcellular Localizations
Cytoplasm. Nucleus.; [Isoform 1]: Nucleus.; [Isoform 2]: Cytoplasm. Nucleus.
Diseases
- Dysautonomia, Familial
- Dysautonomia
- Sclerosis
- Primary Lateral Sclerosis
- Amyotrophic Lateral Sclerosis
- Carcinoma
- Nervousness
- Embryonal Carcinoma
- Multiple Organ Failure
- Motor Neuron Disease
- Genomic Instability
- Melanoma
Interacting Proteins
- ELP1
Pathways
- Histone Acetylation
- Trna Modification
- Cell Cycle
- Translation
- Hypersensitivity
- Gene Silencing
- Exocytosis
- Methylation
- Protein Phosphorylation
- Cell Proliferation
- Dna Repair
- Alpha-tubulin Acetylation
- Demethylation
PTMs
- Acetylation
- Phosphorylation
- Deacetylation
- Methylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ELP3
bosterbio.com/bosterbio-gene-info-cards/ELP3
References
PMID: 11714725 by Hawkes N.A., et al. Purification and characterization of the human elongator complex.
PMID: 11818576 by Kim J.H., et al. Human Elongator facilitates RNA polymerase II transcription through chromatin.