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- Table of Contents
EP300 Antibodies
AND EP300 ELISA kits, EP300 Proteins
Many biological assays use antibodies to detect EP300, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with EP300 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop EP300 antibodies...
Designing a Western blot for EP300? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the EP300 Western Blot GuideEP300 Infographic by Boster Bio
All EP300 Products
Product
Figures
Specificity
Applications
Price
Anti-KAT3B/p300/EP300 Antibody Picoband®
5 Citations
Human, Mouse
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A00117
100 μg/vial
Cat # A00117
100 μg/vial
Anti-KAT3B/p300/EP300 Antibody Picoband®
1 Citations
Human, Mouse, Rat
IHC, WB
$370
Cat # PB9178
100 μg/vial
Cat # PB9178
100 μg/vial
Human, Mouse, Rat
ELISA
$480
Cat # EKC1420
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1420
1 kit, containing one 96-well plate and all necessary reagents
EP300 Overview
Facts about Histone acetyltransferase p300.
Histone acetyltransferase p300 (EP300)
Functions as histone acetyltransferase and regulates transcription via chromatin remodeling (PubMed:23415232, PubMed:23934153, PubMed:8945521). Histone acetylation gives an epigenetic tag for transcriptional activation (PubMed:23415232, PubMed:23934153, PubMed:8945521).
Mediates acetylation of histone H3 at'Lys-122' (H3K122ac), a modification that localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability. Mediates acetylation of histone H3 at'Lys-27' (H3K27ac) (PubMed:23911289).
Gene Information
| Human | |
|---|---|
| Gene Name: | EP300 |
| Uniprot: | Q09472 |
| Entrez: | 2033 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
E1A binding protein p300; E1A-associated protein p300; E1A-binding protein, 300kD; EC 2.3.1; EC 2.3.1.48; EP300; histone acetyltransferase p300; KAT3B; p300 HAT; p300; RSTS2
Molecular Weight
Mass (kDA):
264.161 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 22q13.2 |
| Sequence: | 22; NC_000022.11 (41092592..41180077) |
Subcellular Localizations
Cytoplasm. Nucleus. Chromosome. Localizes to active chromatin: Colocalizes with histone H3 acetylated and/or crotonylated at 'Lys-18' (H3K18ac and H3K18cr, respectively) (PubMed:25818647). In the presence of ALX1 relocalizes from the cytoplasm to the nucleus. Colocalizes with ROCK2 in the nucleus (PubMed:12929931).
Diseases
- Neoplasms
- Malignant Neoplasms
- Carcinoma
- Leukemia
- Cell Transformation, Neoplastic
- Mammary Neoplasms
- Inflammation
- Malignant Neoplasm Of Breast
- Rubinstein-taybi Syndrome
- Hypoxia
- Retinoblastoma
- Hypertrophy
Interacting Proteins
- ALKBH4
- APEX1
- ASH2L
- AUTS2
- BRD7
- CDK2
- CITED2
- COPS2
- CREB1
- Creb1
Pathways
- Cell Cycle
- Histone Acetylation
- Localization
- Cell Differentiation
- Cell Proliferation
- Cell Growth
- Pathogenesis
- Cell Death
- Chromatin Remodeling
- Cell Cycle Arrest
- Methylation
- S Phase
- Regulation Of Gene Expression
PTMs
- Acetylation
- Phosphorylation
- Deacetylation
- Methylation
- Ubiquitination
- Cleavage
Research Areas
- Apoptosis
- Autophagy
- Breast Cancer
- Cancer
- Cell Cycle and Replication
- Cellular Markers
- Chromatin Research
- DNA Repair
- HIF Target Genes
- Hypoxia
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/EP300
bosterbio.com/bosterbio-gene-info-cards/EP300
References
PMID: 7523245 by Eckner R., et al. Molecular cloning and functional analysis of the adenovirus E1A- associated 300-kD protein (p300) reveals a protein with properties of a transcriptional adaptor.
PMID: 10824998 by Chaffanet M., et al. MOZ is fused to p300 in an acute monocytic leukemia with t(8;22).
2 Publications of Boster EP300 Antibodies & ELISA Kits
- PubMed ID: 10.1016/j.scib.2021.01.027, MAFG-AS1/MAFG positive feedback loop contributes to cisplatin resistance in blad...
- PubMed ID: 10.1007/s11655-011-0693-3, Effect of artemisinin combined with glucocorticoid on the expressions of glucoco...
*More publications can be found for each product on its corresponding product page