RNA-binding protein EWS (EWSR1)

Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) can play a role in the tumorigenic process.

They may disturb gene expression by imitating, or interfering with the normal use of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.