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- Table of Contents
RNA-binding protein EWS Antibodies
AND EWSR1 ELISA kits, RNA-binding protein EWS Proteins
Many biological assays use antibodies to detect RNA-binding protein EWS, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with RNA-binding protein EWS in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop RNA-binding protein EWS antibodies...
Designing a Western blot for RNA-binding protein EWS? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the EWSR1 Western Blot GuideEWSR1 Infographic by Boster Bio
All EWSR1 Products
Product
Figures
Specificity
Applications
Price
Human
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # M00592-3
100 μg/vial
Cat # M00592-3
100 μg/vial
Human
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # M00592-2
100 μg/vial
Cat # M00592-2
100 μg/vial
Human, Mouse, Rat
Flow Cytometry, IP, IF, IHC, ICC, WB
$370
Cat # PB9585
100 μg/vial
Cat # PB9585
100 μg/vial
Human, Monkey, Mouse
IHC, WB
$370
Cat # M00589
100 μg/vial
Cat # M00589
100 μg/vial
Human, Mouse, Rat
IF, IHC, ICC, WB
$370
Cat # M00589-2
100 μl/vial
Cat # M00589-2
100 μl/vial
Human
IF, IHC, WB
$523
Cat # M00589-1
100 µl
Cat # M00589-1
100 µl
EWSR1 Overview
Facts about RNA-binding protein EWS.
RNA-binding protein EWS (EWSR1)
Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) can play a role in the tumorigenic process.
They may disturb gene expression by imitating, or interfering with the normal use of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.
Gene Information
| Human | |
|---|---|
| Gene Name: | EWSR1 |
| Uniprot: | Q01844 |
| Entrez: | 2130 |
Family
| Belongs to: |
|---|
| RRM TET family |
Alternative Names
bK984G1.4; Ewing sarcoma breakpoint region 1 protein; Ewing sarcoma breakpoint region 1; Ewings sarcoma EWS-Fli1 (type 1) oncogene; EWS oncogene; EWSRNA-binding protein EWS
Molecular Weight
Mass (kDA):
68.478 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 22q12.2 |
| Sequence: | 22; NC_000022.11 (29268254..29300523) |
Tissue Specificity
Ubiquitous.
Subcellular Localizations
Nucleus. Cytoplasm. Cell membrane. Relocates from cytoplasm to ribosomes upon PTK2B/FAK2 activation.
Diseases
- Neoplasms
- Sarcoma
- Ewings Sarcoma-primitive Neuroectodermal Tumor (pnet)
- Chromosomal Translocation
- Soft Tissue Neoplasms
- Malignant Paraganglionic Neoplasm
- Neuroectodermal Tumors
- Sarcoma, Clear Cell
- Bone Neoplasms
- Feline Urological Syndrome
- Malignant Neoplasms
- Neuroectodermal Tumor, Primitive
Interacting Proteins
- ATPAF2
- EP300
- FUS
- KAT5
- MAPK1IP1L
- PEF1
- PLSCR1
- PRMT1
- PRR13
- SEC24A
Pathways
- Localization
- Interphase
- Oncogenesis
- Pathogenesis
- Reverse Transcription
- Cell Differentiation
- Metaphase
- Rna Processing
- Transport
- Pigmentation
- Cell Cycle
- Cell Migration
- Gene Silencing
PTMs
- Phosphorylation
Research Areas
- Cancer
- Cellular Markers
- Neuroscience
- Tumor Suppressors
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/EWSR1
bosterbio.com/bosterbio-gene-info-cards/EWSR1
References
PMID: 1522903 by Delattre O., et al. Gene fusion with an ETS DNA-binding domain caused by chromosome translocation in human tumours.
PMID: 8307570 by Plougastel B., et al. Genomic structure of the EWS gene and its relationship to EWSR1, a site of tumor-associated chromosome translocation.