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- Table of Contents
EIF3F Antibodies
AND EIF3F ELISA kits, EIF3F Proteins
Many biological assays use antibodies to detect EIF3F, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with EIF3F in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop EIF3F antibodies...
Designing a Western blot for EIF3F? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the EIF3F Western Blot GuideDesigning an IHC experiment for EIF3F? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the EIF3F IHC GuideEIF3F Infographic by Boster Bio
All EIF3F Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, Flow Cytometry, IP, WB
$370
Cat # A04765-2
100 μg/vial
Cat # A04765-2
100 μg/vial
EIF3F Overview
Facts about Eukaryotic translation initiation factor 3 subunit F.
Eukaryotic translation initiation factor 3 subunit F (EIF3F)
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre- initiation complex (43S PIC).
The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632).
Gene Information
| Human | |
|---|---|
| Gene Name: | EIF3F |
| Uniprot: | O00303 |
| Entrez: | 8665 |
Family
| Belongs to: |
|---|
| eIF-3 subunit F family |
Alternative Names
eIF3 p47; eIF-3-epsilon; eIF3-epsilon; eIF3f; eIF3-p47; EIF3S5eukaryotic translation initiation factor 3 subunit F; Eukaryotic translation initiation factor 3 subunit 5; eukaryotic translation initiation factor 3, subunit 5 (epsilon, 47kD); eukaryotic translation initiation factor 3, subunit 5 epsilon, 47kDa; eukaryotic translation initiation factor 3, subunit F
Molecular Weight
Mass (kDA):
37.564 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 11p15.4 |
| Sequence: | 11; NC_000011.10 (7987337..8001852) |
Subcellular Localizations
Cytoplasm.
Diseases
- Malignant Neoplasms
- Neoplasms
- Malignant Neoplasm Of Pancreas
- Melanoma
- Cell Transformation, Neoplastic
- Virus Diseases
- Bronchitis
- Neoplasm Metastasis
- Thoracic Outlet Syndrome
- Pancreatic Neoplasm
- Infective Disorder
- Adenocarcinoma
Interacting Proteins
- CDK11B
- EIF3B
- EIF3H
- EIF3M
- FBXO32
- GLE1
- MSH4
- POU6F2
Pathways
- Translation
- Cell Proliferation
- Pathogenesis
- Pollen Germination
- Programmed Cell Death
- Cell Development
- Proteolysis
- Endocytosis
- Embryo Development
- Cytokinesis
- Cell Division
- Reverse Transcription
PTMs
- Phosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/EIF3F
bosterbio.com/bosterbio-gene-info-cards/EIF3F
References
PMID: 9341143 by Asano K., et al. Structure of cDNAs encoding human eukaryotic initiation factor 3 subunits. Possible roles in RNA binding and macromolecular assembly.
PMID: 12446680 by Shi J., et al. The p34cdc2-related cyclin-dependent kinase 11 interacts with the p47 subunit of eukaryotic initiation factor 3 during apoptosis.