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Facts about Fatty acid-binding protein, liver.
Binds free fatty acids and their coenzyme A derivatives, bilirubin, and a few other little molecules in the cytoplasm. May be involved in intracellular lipid transport (By similarity).
Human | |
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Gene Name: | FABP1 |
Uniprot: | P07148 |
Entrez: | 2168 |
Belongs to: |
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calycin superfamily |
FABP1; FABPL; fatty acid binding protein 1, liver; fatty acid-binding protein, liver; LFABP; L-FABP; L-FABPFatty acid-binding protein 1; Liver-type fatty acid-binding protein
Mass (kDA):
14.208 kDA
Human | |
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Location: | 2p11.2 |
Sequence: | 2; NC_000002.12 (88122982..88128062, complement) |
Cytoplasm.
Boster Bio is an online laboratory that specializes in the analysis of FABP1 gene transcripts. This software can be used for many types research including species and applications. Boster Bio can receive product credits if researchers submit their results. It is also accessible to scientists from all over the world. Read on to find out more about the advantages of using this marker. Nearly all mammals, including humans, have the FABP1 gene.
The FABP1 marker was proposed as a marker for kidney transplant function as a sensitive biomarker to detect acute liver damage due to hepatocellular injury in transplant recipients, and a prognostic instrument for chronic Hepatitis C infection. In a controlled trial FABP1 was shown to be more sensitive than aminotransferases. It is released into bloodstream when hepatocytes have been damaged.
Clear cell RCC is the most common form of renal cancer and has the most bleak prognosis. The current study was solely focused on RCC with clear cells. The objective of the study was to determine the expression of B-FABP1 and the L-FABP1 genes in the patient population, compare these data with clinicopathological parameters, and assess the survival data of patients identified with FABP1 in RCC tissue microarray.
The H-FABP study, that relied on data from chest pain patients, is a good example of an ongoing research study that evaluates the effectiveness of HFABP in early diagnosis of UA. This study shows that H-FABP is an excellent indicator of UA however, more studies are required to evaluate its utility in diagnosing the condition. This study is a small sample size.
The FABP1 gene encodes a protein that binds to fatty acids in the liver. The protein is found in the liver's hepatocytes , as well as in the small intestine. FABP1 tissue content in the human intestinal can range from 26-198 mg/g. Urinary FABP1 is better suited to early detection of kidney damage. Prechylomicron vesicles can also be formed in the endoplasmic retina due to this gene.
The si-FABP4 plasmid has been developed by GenePharma in China. It contains full-length mouse FABP4 which was subcloned into pcDNA3.1. As a negative test, a pcDNA3.1 vector control was used. The plasmids then were transfected into cells with X-treme Gene HP Reagent. Two milligrams of DNA were mixed in Opti-MEM(r) and 48 hours later, real-time PCR was employed to determine the presence the plasmid.
The pcDNA3.1–FABP4 is designed to reduce the expression of genes essential to mitochondrial metabolism of fatty acids. FABP4 silencing decreases the expression of several enzymes that metabolize lipids, reduces mitochondrial content, and reduces ATP levels. Boster Bio offers a plasmid that is containing FABP4 overexpression to make it more effective for research in cell-culture.
The cytoplasm of a cell is home to the pcDNA3.1–FABP4 gene. In our experiments, FABP4 silencing decreased the intensity of red fluorescence, and reduced the ratio between green and red by 50 percent. The FABP4 gene was activated, which increased the ratio of red to green. As you can see, FABP4 plays a variety roles in cells and is involved in the regulation of signaling pathways and transcription.
CCAT1 regulates FA metabolism. In addition to its function in FA metabolism, CCAT1 binds to FABP5. CCAT1 also regulates downstream genes, including LUAD via PI3K/AKT/mTOR Signalling. FABP5-CCAT1 interaction may play a crucial role in LUAD tumorigenesis.
The FABP1 ELISA Kits for humans are used to identify the FABP1 marker in saliva or in serum. The kits aren't clinically validatedand therefore cannot be used to diagnose. They are available in different formats including sandwich kits. Human L-FABP is captured with biotinylated tracer antibodies and then it is reacted with peroxidase enzymes to form the product that is fluorescent.
ELISA kits for FABP1 are a fast and accurate method to measure this protein. The kits come with validation data and are manufactured of top-quality reagents. They could contain recombinant or natural proteins, or the FABP1 marker. The FABP1 assay contains 0.05% proclin 300 as a benchmark. The lowest detectable dose for this marker is 0.58 ng/mL.
Human FABP1 is a biomarker for kidney disease. Early nephropathy sufferers can be identified by the presence of FABP1 urine. The FABP1 marker is present in the proximal tubule, and the presence of FABP1 in urine can be a sign of kidney damage. FABP1 urine tests can be utilized in Japan to assess diabetic patients. The FABP1 urine kit can help doctors determine if the patient has developed diabetic kidney disease.
The ELISA kits for FABP1 markers are helpful in various clinical settings. They are useful in detecting early symptoms of liver disease or hepatitis. For instance, FABP1 levels can be determined in a short period of time, allowing doctors to determine the presence of a particular disease state early. The method of testing used can influence the sensitivity of these kits. There are several types of FABP markers.
You've come to the right spot If you're looking to create custom in vitro diagnostic antibodies for the FABP1 marker. Creative Biolabs offers custom services that target fatty acid binding protein A small cytoplasmic protein found in tissues that exhibit active metabolic processes for fatty acids. This protein is responsible for long-chain fatty acid transfer within cells. If you're interested in customized FABP1 antibody development services for your research, then you've come to the right place.
The FABP1 gene is present in all cell types and is a member of the Fatty Acid Binding Protein family. The cytoplasmic, small-sized protein is involved in the transport and translocation of various fats as well as fatty acids. It is also thought to play a role in cholesterol uptake, translocation and metabolism of fatty acids. In addition it is believed to connect to coenzyme A derivatives.
PMID: 3838309 by Chan L., et al. Human liver fatty acid binding protein cDNA and amino acid sequence. Functional and evolutionary implications.
PMID: 3838313 by Lowe J.B., et al. Human liver fatty acid binding protein. Isolation of a full length cDNA and comparative sequence analyses of orthologous and paralogous proteins.
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