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- Table of Contents
FADD Antibodies
AND FADD ELISA kits, FADD Proteins
Many biological assays use antibodies to detect FADD, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with FADD in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop FADD antibodies...
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FADD Infographic by Boster Bio
All FADD Products
Product
Figures
Specificity
Applications
Price
Human
ELISA
$480
Cat # EKC1206
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1206
1 kit, containing one 96-well plate and all necessary reagents
Human
ELISA
$540
Cat # EKC2030
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2030
1 kit, containing two 96-well plates and all necessary reagents
Mouse
ELISA
$540
Cat # EKC2636
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2636
1 kit, containing two 96-well plates and all necessary reagents
Human
Flow Cytometry, WB
$523
Cat # M00237-2
100 µl
Cat # M00237-2
100 µl
FADD Overview
Facts about FAS-associated death domain protein.
FAS-associated death domain protein (FADD)
Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 into the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation.
Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a part in the positive regulation of interferon signaling.
Gene Information
| Human | |
|---|---|
| Gene Name: | FADD |
| Uniprot: | Q13158 |
| Entrez: | 8772 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
FADD; Fas (TNFRSF6)-associated via death domain; FAS-associated death domain protein; FAS-associating death domain-containing protein; GIG3; Growth-inhibiting gene 3 protein; Mediator of receptor induced toxicity; mediator of receptor-induced toxicity; MGC8528; MORT1; MORT1Fas-associating protein with death domain; protein FADD
Molecular Weight
Mass (kDA):
23.279 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 11q13.3 |
| Sequence: | 11; NC_000011.10 (70203296..70207390) |
Tissue Specificity
Expressed in a wide variety of tissues, except for peripheral blood mononuclear leukocytes.
Diseases
- Malignant Neoplasms
- Neoplasms
- Carcinoma
- Leukemia
- Malignant Paraganglionic Neoplasm
- Inflammation
- Lymphoma
- Mammary Neoplasms
- Malignant Neoplasm Of Prostate
- Prostatic Neoplasms
- Adenocarcinoma
- Malignant Neoplasm Of Breast
- Liver Carcinoma
Interacting Proteins
- CASP8
- FAS
- Fas
- FASLG
- LRRK2
- MBD4
- MYD88
- PARK7
- PLK1
- RIPK1
Pathways
- Cell Death
- Induction Of Apoptosis
- Cell Cycle
- Cell Proliferation
- Pathogenesis
- Programmed Cell Death
- Localization
- Sensitization
- Cell Growth
- Immune Response
- Autophagy
- Apoptotic Process
- Cell Killing
PTMs
- Cleavage
- Phosphorylation
- Ubiquitination
- Methylation
- Oxidation
- Dephosphorylation
- Acetylation
- Biotinylation
- Demethylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/FADD
bosterbio.com/bosterbio-gene-info-cards/FADD
References
PMID: 7538907 by Chinnaiyan A.M., et al. FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis.
PMID: 7536190 by Boldin M.P., et al. A novel protein that interacts with the death domain of Fas/APO1 contains a sequence motif related to the death domain.
1 Publications of Boster FADD Antibodies & ELISA Kits
- PubMed ID: 10.1016/j.biopha.2018.09.024, Scutellarein selectively targets multiple myeloma cells by increasing mitochondr...
*More publications can be found for each product on its corresponding product page