FAS-associated death domain protein (FADD)

Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 into the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation.

Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a part in the positive regulation of interferon signaling.