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- Table of Contents
FADD Antibodies
AND FADD ELISA kits, FADD Proteins
Many biological assays use antibodies to detect FADD, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with FADD in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop FADD antibodies...
Designing a Western blot for FADD? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the FADD Western Blot GuideFADD Infographic by Boster Bio
All FADD Products
Product
Figures
Specificity
Applications
Price
Anti-Caspase-8/CASP8 Antibody Picoband®
8 Citations
Human
ELISA, Flow Cytometry, WB
$370
Cat # A00042-3
100 μg/vial
Cat # A00042-3
100 μg/vial
Human, Mouse, Rat
ELISA, IHC, WB
$370
Cat # A01295-1
100 μg/vial
Cat # A01295-1
100 μg/vial
Anti-Caspase 8/CASP8 Antibody Picoband®
2 Citations
Human, Mouse, Rat
ELISA, WB
$370
Cat # A00042-1
100 μg/vial
Cat # A00042-1
100 μg/vial
Anti-Caspase-8/CASP8 Antibody Picoband®
1 Citations
Human
Flow Cytometry, WB
$370
Cat # A00042-2
100 μg/vial
Cat # A00042-2
100 μg/vial
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, IHC-P, ICC, WB
$481
Cat # A01295-2
0.1 mg
Cat # A01295-2
0.1 mg
Human
Flow Cytometry, WB
$523
Cat # M00237-2
100 µl
Cat # M00237-2
100 µl
Mouse
ELISA
$540
Cat # EKC2636
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2636
1 kit, containing two 96-well plates and all necessary reagents
Human
ELISA
$540
Cat # EKC2030
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2030
1 kit, containing two 96-well plates and all necessary reagents
Human
ELISA
$480
Cat # EKC1206
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1206
1 kit, containing one 96-well plate and all necessary reagents
FADD Overview
Facts about FAS-associated death domain protein.
FAS-associated death domain protein (FADD)
Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 into the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation.
Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a part in the positive regulation of interferon signaling.
Gene Information
| Human | |
|---|---|
| Gene Name: | FADD |
| Uniprot: | Q13158 |
| Entrez: | 8772 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
FADD; Fas (TNFRSF6)-associated via death domain; FAS-associated death domain protein; FAS-associating death domain-containing protein; GIG3; Growth-inhibiting gene 3 protein; Mediator of receptor induced toxicity; mediator of receptor-induced toxicity; MGC8528; MORT1; MORT1Fas-associating protein with death domain; protein FADD
Molecular Weight
Mass (kDA):
23.279 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 11q13.3 |
| Sequence: | 11; NC_000011.10 (70203296..70207390) |
Tissue Specificity
Expressed in a wide variety of tissues, except for peripheral blood mononuclear leukocytes.
Diseases
- Malignant Neoplasms
- Neoplasms
- Carcinoma
- Leukemia
- Malignant Paraganglionic Neoplasm
- Inflammation
- Lymphoma
- Mammary Neoplasms
- Malignant Neoplasm Of Prostate
- Prostatic Neoplasms
- Adenocarcinoma
- Malignant Neoplasm Of Breast
- Liver Carcinoma
Interacting Proteins
- CASP8
- FAS
- Fas
- FASLG
- LRRK2
- MBD4
- MYD88
- PARK7
- PLK1
- RIPK1
Pathways
- Cell Death
- Induction Of Apoptosis
- Cell Cycle
- Cell Proliferation
- Pathogenesis
- Programmed Cell Death
- Localization
- Sensitization
- Cell Growth
- Immune Response
- Autophagy
- Apoptotic Process
- Cell Killing
PTMs
- Cleavage
- Phosphorylation
- Ubiquitination
- Methylation
- Oxidation
- Dephosphorylation
- Acetylation
- Biotinylation
- Demethylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/FADD
bosterbio.com/bosterbio-gene-info-cards/FADD
References
PMID: 7538907 by Chinnaiyan A.M., et al. FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis.
PMID: 7536190 by Boldin M.P., et al. A novel protein that interacts with the death domain of Fas/APO1 contains a sequence motif related to the death domain.
12 Publications of Boster FADD Antibodies & ELISA Kits
- PubMed ID: 10.3892/or.2015.4530, Redox cycling of a copper complex with benzaldehyde nitrogen mustard-2-pyridine ...
- PubMed ID: 10.3892/ijo.2015.3039, Autophagy is involved in recombinant Newcastle disease virus (rL-RVG)-induced ce...
- PubMed ID: 10.1248/bpb.b13-00794, Involvement of substance P/neurokinin-1 receptor in the analgesic and anticancer...
- PubMed ID: 10.1016/j.biopha.2018.09.024, Scutellarein selectively targets multiple myeloma cells by increasing mitochondr...
- PubMed ID: 33392195, Zhou L,Yu W,Jayabalan DS,Niesvizky R,Jaffrey SR,Huang X,Xu G.Caspase-8 Inhibitio...
- PubMed ID: 20081872, Inhibition of proliferation of prostate cancer cell line, PC-3, in vitro and in ...
- PubMed ID: 26261530, Protective effect of RIP and c-FLIP in preventing liver cancer cell apoptosis in...
- PubMed ID: 29767253, Inhibitory activity of apogossypol in human prostate cancerin vitroandin vivo
- PubMed ID: 27275821, Intravenous Administration Is an Effective and Safe Route for Cancer Gene Therap...
- PubMed ID: 22188816, Inhibition of proliferation of prostate cancer cell line, PC-3, in vitro and in ...
- PubMed ID: 28032492, Croton Tiglium Extract Induces Apoptosis via Bax/Bcl-2 Pathways in Human Lung Ca...
- PubMed ID: 26552967, 2-DG-Regulated RIP and c-FLIP Effect on Liver Cancer Cell Apoptosis Induced by T...
*More publications can be found for each product on its corresponding product page